Total Intravenous Anesthesia (TIVA)/Sevoflurane Initiated Intravenous Anesthesia (SIIVA) in Pediatric Patients

Launched by WAKE FOREST UNIVERSITY HEALTH SCIENCES · Apr 27, 2023

Keywords

ClinConnect Summary

This clinical trial is studying two methods of anesthesia—Total Intravenous Anesthesia (TIVA) and Sevoflurane Initiated Intravenous Anesthesia (SIIVA)—in young children who need surgery. The goal is to understand which method helps children wake up (extubate) successfully after surgery. Researchers believe that the way these types of anesthesia are used may affect how well children recover compared to traditional inhaled anesthesia.

To participate in this study, children must be under 10 years old and scheduled for surgery that requires a breathing tube. They should be receiving general anesthesia using either TIVA or SIIVA, and their exposure to a specific inhaled anesthetic called Sevoflurane must be very low when they are waking up. However, children with certain health issues, like those who need oxygen at home or have specific heart conditions, cannot take part. If eligible, participants will be closely monitored during and after their surgery to see how well they recover from the anesthesia. This trial is currently recruiting participants, so it could be a good opportunity for families looking for options in pediatric anesthesia care.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Pediatric patients \<10 years of age
• • Undergoing elective or emergency surgery with planned airway instrumentation with an endotracheal tube (ETT)
• • Patients having general anesthesia with a planned SIIVA or TIVA technique
• • Patients with an end tidal agent concentration of Sevoflurane\<0.1% at the time of emergence and extubation
• • following sevoflurane induction to place IV
• Exclusion Criteria:
• • History of home oxygen use or ventilator dependence
• • Patients with cyanotic congenital heart disease
• • Patients undergoing anesthesia for imaging procedures alone
• • Patients intended to be managed with supraglottic airway
• • Patients having an anesthesia time \< 30 minutes
• • Monitored Anesthesia Care (not general anesthesia)
• • Patients with contraindication to receiving Propofol (i.e. mitochondrial myopathy)