Investigating Cognitive Impairment in Young Patients With Cancer Prospectively

Launched by RIGSHOSPITALET, DENMARK · Apr 24, 2023

Keywords

ClinConnect Summary

The MyBrain study is looking at how chemotherapy affects the brain function of children, teenagers, and young adults who are being treated for cancer. This includes tracking their memory, attention, and the electrical activity of their brains during and after treatment. The goal is to understand how chemotherapy might impact thinking and learning abilities, which is sometimes referred to as "chemo-brain."

To participate in this study, patients must be newly diagnosed with a type of cancer (not affecting the brain) and plan to undergo chemotherapy at University Hospital Copenhagen. They should be between the ages of 7 and 29 at the time of diagnosis. Each patient will be paired with a control participant, like a friend or family member, who is close in age. Participants will undergo tests to assess their cognitive skills and brain activity. It's important to note that individuals with certain conditions, such as severe mental disabilities or those who have received previous cancer treatments, cannot join the study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients who are newly diagnosed with a non-CNS cancer and will undergo chemotherapy at University Hospital Copenhagen, Rigshospitalet.
• • At the age of 7-29 years at diagnosis
• • Each patient is matched (1:1) with a control participant within 24 months of age. The controls are recruited from the patient's own social circle and can be a friend, partner, or close family (sibling or cousin).
• Exclusion Criteria:
• • Unable to speak and understand Danish
• • Severe intellectual disability or mental health disorder that hinders participation
• • Brain metastases,
• • Terminal illness
• • Have had a previous chemotherapy or radiotherapy treatment