I Can Move with Purpose Now! a Pilot Lifestyle Intervention Study in Myeloproliferative Neoplasm Patients

Launched by MASSACHUSETTS GENERAL HOSPITAL · May 1, 2023

Keywords

ClinConnect Summary

The clinical trial titled "I Can Move With Purpose Now!" is looking to help patients with certain blood disorders, specifically myeloproliferative neoplasms (MPNs), improve their health through a special program called the Cardiac Lifestyle Program (CLP). This 12-week program focuses on teaching participants how to be more active and eat healthier foods. The main goal is to see if patients can complete the program successfully and benefit from the changes in their lifestyle.

To be eligible for this trial, participants must be 18 years or older and have a diagnosis of a myeloproliferative disorder like essential thrombocythemia or polycythemia vera. They also need to have at least one risk factor for heart disease, such as being overweight or having high blood pressure. Patients with certain severe conditions or injuries that prevent them from exercising will not be able to join. Those who participate can expect to engage in tailored nutrition and physical activities designed to improve their overall health and well-being. This is a great opportunity for patients looking to make positive lifestyle changes while being supported by a structured program.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • -≥18 years of age
• • Diagnosed with an MPN by WHO 2016 criteria,22 including essential thrombocythemia (ET), polycythemia vera (PV), prefibrotic myelofibrosis (pre-MF), myelofibrosis (MF), and MPN not otherwise specified (NOS). Within MF patients, only patients who are low or intermediate-1 risk by the Dynamic International Prognostic Scoring System (DIPSS) are eligible.23 All risk groups are eligible for the remaining MPN subtypes.
• • Eastern Cooperative Oncology Group (ECOG) performance status 0-1
• • Must have at least one cardiovascular risk factor including: Body mass index (BMI) \>25 kg/m2, hypertension, hyperlipidemia, diabetes mellitus or pre-diabetes or metabolic syndrome, or any prior history of cardiovascular disease, transient ischemic attack, stroke, or peripheral vascular disease. Patients not meeting any cardiovascular risk criteria must receive prior approval from the PI to participate in this study.
• Exclusion Criteria:
• • -- MF patients with intermediate-2 or high-risk disease by DIPSS
• • ECOG performance status \>2.
• • Any injury or medical condition that would prohibit being able to safely perform exercise, as determined by the treating physician.