Pulmonary Immune Cell-microbiome Interactions in the Healthy Lung

Launched by HVIDOVRE UNIVERSITY HOSPITAL · Apr 27, 2023

Keywords

ClinConnect Summary

This clinical trial, titled "Pulmonary Immune Cell-microbiome Interactions in the Healthy Lung," aims to understand how immune cells and the bacteria living in our lungs interact in healthy individuals. Researchers want to learn about the types of immune cells present, how they are activated, and how these cells communicate with the surrounding environment, including important molecules known as cytokines. By doing this, they hope to establish a baseline of what a healthy lung should look like in terms of immune function and microbiome composition.

To participate in this study, you need to be a healthy adult between the ages of 40 and 75, and you must not have any lung diseases, immune system issues, or active cancer. Participants will undergo a procedure called bronchoscopy, which allows doctors to collect samples from the lungs to analyze the immune cells and bacteria present. This research is important as it could help us better understand lung health and how our immune system works in harmony with our microbiome.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Men and women
• • Age 40 to 75
• Exclusion Criteria:
• • Immune deficiency
• • Lung disease
• • Active cancer or infection
• • Absolute contraindications for bronchoscopy
• • Untreated malignant arrhythmia
• • Documented or suspected intracranial hypertension (intracranial pressure ≥ \> 15 mmHg)
• • One-lung ventilation
• • Severe coagulopathy