Evaluation of Brain Health and Surgical Efficacy in Patients With Carotid Artery Stenosis

Launched by NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE · Apr 28, 2023

Keywords

ClinConnect Summary

This clinical trial is designed to study how surgery for carotid artery stenosis (a condition where the arteries in the neck are narrowed) affects brain health and thinking abilities. Researchers want to understand how recovery in blood flow and brain structure relates to cognitive function before and after the surgery. They will also look at patients' heart health and other factors to help predict the risk of developing brain-related diseases after the procedure.

To be eligible for this trial, participants must be over 50 years old and able to complete some simple mental tests. They should need surgery for carotid artery stenosis and can have normal thinking abilities or mild cognitive issues. However, individuals with certain health problems, a history of serious mental illness, or those participating in other clinical studies won't be able to take part. If you join the study, you can expect to undergo evaluations before and after the surgery, which will help researchers learn more about how these factors impact brain health.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Aged over 50 years old;
• • Conscious and capable of completing neuropsychological scales
• • Clinical detection of carotid artery stenosis requires surgical treatment;
• • Compliant with carotid artery stenting or carotid endarterectomy surgical standards
• • Individuals with normal cognition and mild cognitive impairment
• Exclusion Criteria:
• • Degree of vascular blockage in other intracranial segments ≥ 50%
• • Have a history of mental illness, nervous system disease (such as stroke) or brain injury with loss of consciousness for more than five minutes;
• • Neurological and psychiatric disorders unrelated to AD (schizophrenia, depression, etc.), post-traumatic stress disorder, obsessive-compulsive disorder, multiple sclerosis, amyotrophic lateral sclerosis)
• • Have a history of alcohol or drug abuse
• • There are contraindications for magnetic resonance imaging examination
• • Those with significant organ dysfunction such as lung, liver, and kidney;
• • Patients with intracranial tumors, infectious diseases, and blood system diseases;
• • Participating in other clinical studies at the same time