Optimization of Saturation Targets and Resuscitation Trial (OptiSTART)

Launched by UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER · May 4, 2023

Keywords

ClinConnect Summary

The OptiSTART trial is a study aimed at finding the best level of oxygen saturation (SpO2) for premature infants during their initial care after birth. Researchers want to determine whether aiming for a higher oxygen saturation level (75th percentile) compared to a lower level (50th percentile) can help these infants survive without developing serious health issues, such as lung disease or problems with brain development. The study will include about 700 infants born between 22 and 30 weeks of gestation who need resuscitation.

Eligible participants must be very premature babies and cannot have certain heart or lung conditions diagnosed before birth. Throughout the trial, all infants will receive standard care, with the only difference being the target levels of oxygen saturation they aim for. Parents can expect to have their infants monitored closely, and the study will track their health outcomes over time to see how the different oxygen levels affect their survival and long-term development. This research is important because it could help improve care for premature infants, ultimately leading to better health outcomes.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • -Neonates with OB gestational age 22-30 weeks
• Exclusion Criteria:
• • Prenatally diagnosed cyanotic congenital heart disease
• • Prenatally diagnosed congenital diaphragmatic hernia
• • Parents request no resuscitation
• • If preductal saturations can not be measured by 3 minutes after pulse oximeter sensor is applied to the newborn