Optimal Resection Technique for Medium-sized (10-20mm) Colorectal Polyps

Launched by UNITY HEALTH TORONTO · Apr 27, 2023

Keywords

ClinConnect Summary

This clinical trial is looking at the best way to remove medium-sized colorectal polyps, which are growths found in the colon that can sometimes lead to cancer if not treated. The researchers want to compare three different methods of removal: Endoscopic Mucosal Resection (EMR), cold EMR, and underwater EMR. By studying these methods, they hope to find out which one results in fewer cases of the polyps coming back and has fewer side effects for patients.

To be eligible for this trial, participants need to be at least 18 years old, have a specific type of polyp that measures between 10 to 20 mm, and complete the bowel preparation recommended by their doctor. It’s important to note that certain conditions, like inflammatory bowel disease or pregnancy, would exclude someone from participating. If someone joins the trial, they can expect to undergo one of the removal techniques under careful monitoring to ensure their safety and well-being throughout the process. This study is not yet recruiting participants, but it aims to improve how we treat these types of polyps in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. The patient (or a legally authorized representative) provides informed consent
• • 2. 18 years of age or older
• • 3. Completion of the endoscopist-recommended bowel preparation
• 4. Presence of one eligible medium-sized polyp:
• • 10-20 mm in size
• • Paris classification of 0-IIa (flat, elevated lesion) on standard white light colonoscopy
• • JNET Type 1 or 2A on magnifying Narrow Band Imaging (NBI) suspecting a sessile serrated lesion, adenoma, or adenoma with low-grade dysplasia.
• Exclusion Criteria:
• • 1. Patient \< 18 years old
• • 2. Inability to provide informed consent
• • 3. Inflammatory Bowel Disease,
• • 4. Familial Polyposis
• • 5. Pregnancy
• • 6. Incomplete bowel preparation
• 7. Patients with ineligible lesion:
• • Paris classification of 0-Ip or 0-Is on standard white light colonoscopy,
• • JNET Type 1 suspecting a hyperplastic polyp, or Type 2B or 3 suspecting a high- grade dysplasia or adenocarcinoma.