Biomarkers and Mechanisms of Disease Progression and Outcome of Aortic Stenosis in Humans

Launched by HEINRICH-HEINE UNIVERSITY, DUESSELDORF · May 5, 2023

Keywords

ClinConnect Summary

This clinical trial is focused on understanding a condition called aortic stenosis, where the heart's aortic valve becomes narrowed, making it harder for the heart to pump blood. Researchers want to learn more about the signs (called biomarkers) and processes that lead to this disease getting worse. By studying images of the heart and other factors, they hope to find out which patients are at higher risk and to explore new treatment options.

To participate in this study, you need to be at least 18 years old and have a moderate case of aortic stenosis, which means you are receiving regular care from a heart doctor. Unfortunately, if you have serious issues that would prevent certain types of imaging tests or if your aortic stenosis is too mild or severe, you may not be eligible. If you join the study, you will be informed about the procedures and will need to give your written consent. The trial is not yet recruiting participants, but it aims to gather important information that could improve care for those with this heart condition.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • The patient has an acquired (tricuspid) moderate aortic valve stenosis, which is the reason for regular outpatient cardiological care.
• • The subject has been informed verbally and in writing about the study and has given written consent to participate in this study.
• • Age \> 18 years
• Exclusion Criteria:
• • The subject has contraindications for the performance of a magnetic resonance imaging or computed tomography (e.g., severe arrhythmias , contrast agent intolerance, a pacemaker, or severe renal insufficiency or severe renal insufficiency or claustrophobia).
• • Presence of only mild or already high-grade acquired tricuspid Aortic valve stenosis
• • Patient with bicuspid aortic valve
• • Inability to follow the instructions of study personnel
• • Lack of written informed consent