Acute Exercise on Brain Insulin Sensitivity

Launched by RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY · May 2, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how a single session of exercise affects insulin sensitivity in the brain, particularly in middle-aged and older adults. Insulin sensitivity refers to how well your body responds to insulin, a hormone that helps control blood sugar levels. The researchers want to see if exercising can improve brain function, which is important for memory and thinking, especially as we age. They are also looking at how this relates to heart health and overall metabolic functioning.

To participate in the study, you need to be between 40 and 80 years old, have a body mass index (BMI) between 25 and 45, and currently do less than 150 minutes of moderate to high-intensity exercise each week. If you are pregnant, have certain health conditions, or take specific medications, you may not be eligible. Participants can expect to engage in exercise sessions and undergo assessments related to brain and heart health. This research aims to shed light on the potential benefits of exercise for cognitive health in aging adults.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Male or female \>40 and \<80 years old.
• • Has a body mass index \>25 and \<45 kg/m2.
• • Physical Activity (\<150 min of moderate/high intensity exercise per week)
• Exclusion Criteria:
• • Subjects who have not been weight stable (\>2 kg weight change in past 3 months)
• • Subjects who are smokers or who have quit smoking \<1 years ago
• • Subjects with abnormal estimated glomerular filtration rate (eGFR).
• • Hypertriglyceridemic (\>400 mg/dl) and hypercholesterolemic (\>260 mg/dl) subjects
• • Hypertensive (\>160/100 mmHg)
• • Subjects with a history of significant metabolic, cardiac, congestive heart failure, cerebrovascular, hematological, pulmonary, gastrointestinal, liver, renal, or endocrine disease or cancer that in the investigator's opinion would interfere with or alter the outcome measures or impact subject safety.
• • Pregnant (as evidenced by positive urine pregnancy test) or nursing women
• • Subjects with contraindications to participation in an exercise
• • Current Pregnancy
• • Currently taking active weight suppression medication (e.g. phentermine, orlistat, lorcaserin, naltrexone-bupropion in combination, liraglutide, benzphetamine, diethylpropion, phendimetrazine)
• • Subjects currently taking medications that affect heart rate and rhythm (i.e. Ca++ channel blockers, nitrates, alpha- or beta-blockers).
• • Known contraindications for MRI imaging