Circulating Biomarker Signatures for the Detection of Gastric Preneoplasia and Cancer

Launched by INSTITUT PASTEUR · May 2, 2023

Keywords

ClinConnect Summary

This clinical trial is focused on identifying specific markers in the blood that could help detect early signs of stomach issues, such as precancerous conditions and gastric cancer. Researchers want to compare blood samples from patients who already have stomach lesions (abnormal areas in the stomach lining) to samples from healthy individuals. This will help them understand if certain biological signals in the blood can indicate the presence of these stomach problems.

To participate, you need to be at least 18 years old and willing to provide a small blood sample (about 2 teaspoons) in addition to what you may already be having done for your regular care. People with untreated gastric lesions or early-stage gastric cancer can join, as well as healthy volunteers without any history of stomach issues. However, individuals with certain health conditions, such as autoimmune diseases or those currently receiving specific treatments, cannot participate. If you join the study, you will help researchers learn more about stomach health, which could lead to better detection and treatment options in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Common
• • 18 years old or highter
• • written informed consent prior to any study procedure
• • Affiliated to a social insurance system
• • Specific to patients with gastric lesions
• • Untreated glandular atrophy (with or without intestinal metaplasia and/or dysplasia) and histologically diagnosed as of 2014
• • Treatment naïve Gastric cancer (distal or proximal adenocarcinoma)
• Exclusion Criteria:
• • Common
• • Autoimmune disease or disease that impacts the immune system (e.g: HIV)
• • Chronic inflammatory disease
• • Known evolutive cancer (excluding gastric cancer)
• • Treated in the last 3 months or currently treated with therapy that interferes with the immune system (e.g. immunosuppressive therapy)
• • Current treatment with long-term corticosteroid therapy
• • Current treatment with long-term nonsteroidal anti-inflammatory drugs
• • Pregnant woman or breastfeeding
• • Patient or healthy volunteer under legal protection (e.g. guardianship)
• • Patient or healthy volunteer currently participating to a clinical trial evaluating either an experimental medical product or a medical device
• • Patient or healthy volunteer currently in custody
• • Specific to Healthy Volunteer
• • Known history of Helicobacter pylori infection
• • Known history of gastric lesions (i.e. chronic gastritis, gastric atrophy, intestinal metaplasia, dysplasia and cancer)