Cough Capture as a Portal Into the Lung

Launched by ALBERT EINSTEIN COLLEGE OF MEDICINE · May 2, 2023

Keywords

ClinConnect Summary

This clinical trial is studying a new, non-invasive way to collect samples from the lungs using cough. Researchers want to find out if they can gather useful information from the cough that can help in diagnosing lung diseases like lung cancer and other respiratory conditions. By optimizing how they collect cough samples, they aim to understand if these samples can provide insights similar to those obtained from more invasive procedures like bronchoscopy, which involves looking inside the lungs with a small camera.

To participate in this trial, individuals must be at least 21 years old and are scheduled to undergo a bronchoscopy for diagnostic reasons. The trial is open to people of all genders and ethnicities, but those with certain medical conditions that could complicate cough collection or bronchoscopy may not be eligible. Participants can expect to provide cough samples, mouthwash samples, and undergo bronchoscopy, allowing researchers to compare these different methods of sample collection. Ultimately, the goal is to improve early detection and treatment of lung diseases, making diagnosis faster and less invasive.

Gender

ALL

Eligibility criteria

• • Inclusion Criteria: All consenting subjects with a clinical indication/imminent bronchoscopy.
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• Inclusion Criteria:
• • Age: minimum age of 21 years
• • Gender: Male and Female adults
• • Ethnicity: All ethnic groups and races.
• • Subjects undergoing bronchoscopy for diagnostic purposes or therapy.
• Exclusion Criteria:
• • Clinical dyspnea or cough precluding comfortable collection of additional cough/mouthwash or bronchoscopy specimens
• • Bleeding diathesis or known coagulopathy precluding endobronchial brushing (e.g. INR\>1.3, PTTr\>1.3), thrombocytopenia 3.0,
• • Unstable angina, Recent myocardial infarction (within 3 months),
• • Uncontrolled congestive heart failure or severe pulmonary hypertension (mean PAP\>75 mmHg).
• • Other contraindication to clinical-indicated bronchoscopy.