Motor Function Efficacy of Pharmacological Treatments Targeting Energy Metabolism, in Parkinson's Patients

Launched by I.R.C.C.S. FONDAZIONE SANTA LUCIA · May 3, 2023

Keywords

ClinConnect Summary

This clinical trial is exploring how certain medications and natural supplements that target energy production in cells can help improve movement and walking in people with Parkinson's disease. Researchers believe that problems with energy production in cells play a significant role in the development of Parkinson's, and they want to see if targeting this issue can help patients feel better and move more easily.

To participate in this study, you need to have been diagnosed with a specific type of Parkinson's that causes stiffness and difficulty moving, and you should have had the disease for at least five years. Other criteria include being stable on your current medications for the last three months and having a good level of mental function. Participants will be monitored closely to assess any changes in their movement and overall health. This trial is not yet recruiting, but it aims to provide valuable insights into new treatment options for people living with Parkinson's disease.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patient with rigid-acinetic bilateral PD form
• • At least 5 years of disease history
• • H\&Y between 2-3.5
• • Stable drug therapy response without any change performed in the 3 months before the study.
• • MMSE\>24/30 (Mini-Mental State Examination)
• • No severe gastrointestinal pathologies.
• Exclusion Criteria:
• • Systemic illness
• • Presence of cardiac pacemaker
• • Presence of deep brain stimulation
• • Presence of severe dysautonomia with marked hypotension
• • Obsessive-Compulsive Disorder (OCD)
• • Major depression
• • Dementia
• • History or active neoplasia
• • Pregnancy
• • Lack of autonomy in walking;
• • Malabsorption and gastrointestinal disorders;
• • Gluten intolerance
• • Ipotiroidism