Exercise Response in Humans With Obesity

Launched by MAYO CLINIC · May 4, 2023

Keywords

ClinConnect Summary

This clinical trial, called "Exercise Response in Humans With Obesity," is exploring how long-term inflammation in the body affects muscle function and how people with obesity respond to exercise. Researchers want to learn more about the relationship between inflammation and exercise, which could help improve fitness and health strategies for individuals with obesity.

To participate in this study, you must be an obese man or woman between the ages of 20 and 45. However, certain health conditions could prevent you from joining, such as diabetes, heart disease, or liver problems. If you decide to take part, you can expect to be involved in activities that assess your muscle function and responses to exercise. This research is important because it aims to provide valuable insights that could lead to better exercise recommendations for those dealing with obesity.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Obese men and women ≥ 20 and ≤ 45 years of age.
• Exclusion Criteria:
• • Diabetes or fasting plasma glucose \>126 mg/dL
• • Anemia (female subjects hemoglobin of \<11 g/dl and male subjects hemoglobin \<12 g/dl)
• • Active coronary artery disease or history of unstable macrovascular disease (unstable angina, myocardial infarction, stroke, and revascularization of coronary, peripheral or carotid artery within 3 months of recruitment)
• • Renal failure (serum creatinine \> 1.5mg/dl)
• • Chronic active liver disease defined as aspartate aminotransferase (AST)\>144 IU/L or alanine transaminase (ALT) \>165 IU/L)
• • Oral warfarin group medications or history of blood clotting disorders.
• • Smoking
• • Pregnancy or breastfeeding
• • Alcohol consumption greater than 2 glasses/day or other substance abuse
• • Untreated or uncontrolled hypothyroidism
• • Debilitating chronic disease (at the discretion of the investigators)