Viral and Epigenetic Influences in CRSwNP

Launched by CENTRE HOSPITALIER DE L'UNIVERSITÉ DE MONTRÉAL (CHUM) · May 10, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how certain viruses and changes in our body's genes might affect a condition called Chronic Rhinosinusitis with Nasal Polyposis (CRSwNP). CRSwNP is characterized by ongoing inflammation in the nasal passages that can lead to the growth of polyps, which are noncancerous growths. Researchers believe that external factors, like viruses, could change how our immune system works and contribute to this condition. They will look for specific changes in genes and how they interact with viruses to help understand what causes CRSwNP and to find new ways to treat it.

To participate in this trial, you must be an adult with CRSwNP who is either doing well after treatment or is scheduled for surgery related to the condition. Healthy volunteers with no nasal symptoms are also welcome. Participants can expect to undergo tests that examine their gene activity and any viruses present in their bodies. This research could lead to the discovery of new treatments for CRSwNP and help us better understand the role of viruses in this disease. If you’re interested in participating, check if you meet the criteria and consider joining this important study!

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • T2 CRSwNP patients with favorable evolution
• • T2 CRSwNP patients undergoing ESS
• • Healthy volonteers with no nasal symptoms and documented normal sense of smell
• Exclusion Criteria:
• • Cystic fibrosis
• • Primary immunodefisciencies