Respiratory Muscle Structure and Function in Mechanically Ventilated Patients and Long-term Outcomes

Launched by UNIVERSITY HEALTH NETWORK, TORONTO · May 10, 2023

Keywords

ClinConnect Summary

The RESPIRE study is a clinical trial that aims to understand how the muscles we use for breathing are affected when patients are on mechanical ventilation in the intensive care unit (ICU). Mechanical ventilation is a process where a machine helps patients breathe when they can't do so on their own. While this can help patients recover, it may also cause weakness in the respiratory muscles, making it harder for them to breathe without assistance later on. The study will look at how these muscles change during ventilation and how this affects patients' long-term quality of life. Additionally, the researchers will explore new ways to use data from the ventilator to predict how well patients will be able to breathe on their own after treatment.

To participate in the study, you must be at least 18 years old and undergoing mechanical ventilation in the ICU within 36 hours of being intubated. Other groups that may be eligible include patients receiving non-invasive ventilation or those who are not on any respiratory support. However, certain individuals, such as those with specific neuromuscular disorders or those who have been on long-term mechanical ventilation, cannot join. If you choose to participate, you'll help researchers learn more about the effects of mechanical ventilation on breathing muscles, which can ultimately improve care for future patients.

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Eligibility criteria

• Cases Inclusion Criteria:
• • • Adult patients ≥18 years of age undergoing invasive mechanical ventilation in the ICU for any reason within 36 hours of intubation
• Control condition A Inclusion Criteria:
• • • Non-invasively ventilated patients in the ICU within 36 hours of initiating non-invasive ventilation
• • Control condition B Inclusion Criteria
• • • Non-ventilated patients admitted to the ICU receiving no respiratory support or oxygen therapy alone, including high flow nasal cannula
• Exclusion Criteria:
• • Patients expected to be extubated within 24 hours of screening for eligibility
• • Patients who have already undergone a SBT at time of screening
• • Patients with a previously diagnosed neuromuscular disorder
• • Patients receiving long-term invasive mechanical ventilation (prior to current hospitalization)
• • Patients who have required previously (during current hospitalization) a period of invasive ventilation in ICU of more than 24 hours
• • Patients who have previously been enrolled in the study
• • Patients for whom post-hospital follow-up may be challenging, e.g. those who reside overseas or who have no fixed address