Oral Vitamin D Supplementation Prevent Peritoneal Dialysis-related Peritonitis

Launched by PEKING UNIVERSITY FIRST HOSPITAL · May 5, 2023

Keywords

ClinConnect Summary

This clinical trial is studying whether taking oral vitamin D can help prevent infections related to peritoneal dialysis, especially after a patient has had an episode of peritonitis (an infection in the abdominal cavity). Researchers want to see if giving vitamin D3 to patients who have low levels of this vitamin can lower their chances of getting peritonitis again. The trial is currently recruiting participants who are at least 18 years old, have been on peritoneal dialysis for over a month, and have low levels of vitamin D in their blood.

Eligible participants will receive either vitamin D3 or a placebo (a pill with no active ingredients) to compare the effects. The study will involve regular follow-ups to monitor health and any side effects. It's important to note that certain individuals, like those with recent severe health issues or specific medical histories, may not qualify to join. This trial could provide valuable information about the role of vitamin D in managing complications for patients undergoing peritoneal dialysis.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Medically stable and receiving peritoneal dialysis for \> 1 month
• • Older than 18 years old
• • Serum 25(OH)D \< 30ng/ml
• • Adequate dialysis on evaluation with weekly Kt/V ≥ 1.5, or (revised time: 2023-7-11) without clinical uremic symptoms
• Exclusion Criteria:
• • Receive Vitamin D2/D3 during the previous 1 month (revised time: 2023-7-11) ;
• • History of allergic reaction to Cholecalciferol;
• • Current or past malignant disease, active hepatitis or hepatic failure, active autoimmune disease, severe digestive malabsorption or an eating disorder, HIV/AIDS;
• • Acute systemic infection, cardiovascular disease, surgery, or trauma in the last month;
• • A high probability of receiving a kidney transplant or transferring to hemodialysis or drop-out due to socioeconomic causes within 6 months;
• • History of kidney transplant;
• • Hemodialysis combined with peritoneal dialysis currently;
• • Pregnant or breastfeeding;
• • Not suitable enrolled assessed by researchers, including patients who could not regular follow-up