Evaluation of Lipoedema Tissue Transcriptome

Launched by UNIVERSITY HOSPITAL SCHLESWIG-HOLSTEIN · May 6, 2023

Keywords

ClinConnect Summary

This clinical trial is studying a condition called lipoedema, which is a painful disorder that causes abnormal fat distribution in women, often worsened by hormonal changes. The researchers want to understand the molecular changes—specifically the RNA patterns—in the tissue of women with lipoedema compared to healthy tissue. By doing this, they hope to uncover the underlying mechanisms that lead to this condition, which is currently not well understood.

If you are a woman aged 18 or older with varying stages of lipoedema (mild, moderate, or severe), or if you have lipohypertrophy (a condition involving excess fat), you may be eligible to participate. The study will involve taking small tissue samples, and participants will be closely monitored throughout the process. It’s important to note that individuals with certain infections, like HIV or hepatitis, or inflammation in the tissue area, cannot participate. This research could help improve our understanding of lipoedema and lead to better treatments in the future.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • 1. Lipohypertrophy: tissue from healthy patients (n=20): Consent-capable female patients ≥18 years of age with lipohypertrophy
• • 2. Lipoedema milde stage: tissue from Lipoedema patients with mild stage 1 (n=20): Consent-capable female patients ≥18 years of age with Lipoedema (Stage 1)
• • 3. Lipoedema moderate stage: tissue from Lipoedema patients with moderate stage 2 (n=20): Consent-capable female patients ≥18 years of age with Lipoedema (Stage 2)
• • 4. Lipoedema severe stage: tissue from Lipoedema patients with severe stage 3 (n=20): Consent-capable female patients ≥18 years of age with Lipoedema (Stage 3)
• Exclusion Criteria:
• • Inflammation in region of interest, HIV, Hepatitis