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Search / Trial NCT05864768

The Role of Diet in Periodontal Inflammation: A Controlled Clinical Study

Launched by G. D'ANNUNZIO UNIVERSITY · May 16, 2023

Trial Information

Current as of June 26, 2025

Recruiting

Keywords

Experimental Gengivitis Nutraceutical Periodontal Inflammation

ClinConnect Summary

The clinical trial titled "The Role of Diet in Periodontal Inflammation" is exploring how different types of diets, specifically vegetarian/vegan versus omnivorous diets, can affect gum health and inflammation. Researchers believe that while bacteria are the main cause of periodontal diseases, the food we eat may influence how severe these conditions become. They want to find out if a vegetarian or vegan diet can provide better protection for gum health compared to a diet that includes meat. To do this, they are studying two groups of participants: one group that eats meat and another group that follows a vegetarian or vegan diet.

If you are between the ages of 65 and 74, in good overall health, and have not smoked or had certain medical conditions like heart disease or diabetes, you might be eligible to participate. Participants will undergo a controlled experiment where mild gum inflammation will be induced, and their responses to the different diets will be observed. This is important because understanding the link between diet and gum health can help people make better choices for their oral health. If you're interested or think you might qualify, please reach out for more information about joining the study.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Optimal systemic health conditions
  • Non-Smoking
  • Absence of cardio-vascular pathologies
  • Absence of pulmonary pathologies
  • Non-diabetic
  • Not pregnant
  • FMPS \<20%
  • FMBS \<20%
  • Omnivorous or vegan/vegetarian diet for at least a year
  • Absence of periodontitis
  • Exclusion Criteria:
  • Smokers
  • Presence of systemic pathologies
  • Presence of cardio-vascular disease
  • Presence of periodontitis
  • FMPS\>20%
  • FMBS\>20%
  • Pregnant women
  • Presence of blood pathologies
  • Taking medicines (hydantoins, nifedipine or cyclosporine)
  • Taking oral contraceptives
  • Bacterial, viral or fungal infections
  • Idiopathic gingival fibromatosis
  • Mucocutaneous disorders
  • Allergic reactions to toothpastes and mouthwashes

About G. D'annunzio University

G. D'Annunzio University, located in Chieti-Pescara, Italy, is a prominent academic institution committed to advancing scientific research and innovation in the health sciences. With a strong emphasis on interdisciplinary collaboration, the university fosters an environment that encourages the development of novel therapeutic strategies and clinical applications. As a clinical trial sponsor, G. D'Annunzio University seeks to contribute to the improvement of patient outcomes through rigorous research methodologies, ethical standards, and a focus on translational medicine. Their dedication to education and research excellence positions them as a key player in the advancement of healthcare solutions.

Locations

Chieti, Ch, Italy

Patients applied

0 patients applied

Trial Officials

Michele Paolantonio, MD; DDS

Principal Investigator

University G. D'Annunzio Chieti-Pescara

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported