Vascular MRI Evaluation in Giant Cell Arteritis (VEGA)

Launched by UNIVERSITY OF PENNSYLVANIA · May 9, 2023

Keywords

ClinConnect Summary

**Trial Summary: Vessel Wall Enhancement in Giant Cell Arteritis**

This clinical trial is investigating how well magnetic resonance imaging (MRI) can help detect inflammation in the arteries that supply blood to the head, brain, and eyes in patients with Giant Cell Arteritis (GCA). GCA, also known as temporal arteritis, can cause serious symptoms like headaches, vision problems, and jaw pain. The study is currently looking for participants who either have a new diagnosis of GCA or are experiencing a relapse of their condition with new or worsening symptoms. To be eligible, participants should have symptoms related to GCA and must be within 14 days of starting or increasing treatment with steroid medications, like prednisone.

Participants in the trial will have an MRI to check for signs of inflammation in their arteries. It's important to know that people with certain medical conditions, such as having a pacemaker or severe kidney issues, may not be able to participate. Additionally, individuals who are pregnant, nursing, or have significant anxiety about being in small spaces (claustrophobia) are also excluded. By participating, individuals will have the opportunity to contribute to research that may improve understanding and treatment of GCA for future patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age 50 years or older
• • First presentation of suspected GCA
• • New or worsening cranial manifestations within 4 weeks of enrollment concerning for active GCA
• • Elevated CRP greater than 1.0 mg/dl
• • Plan to undergo temporal artery biopsy or ultrasound for diagnosis
• Exclusion Criteria:
• * Contra-indication to receiving MRI including:
• • Implanted medical devices, pacemaker, and metallic foreign fragments inside body/orbits Known gadolinium allergy Women who are pregnant or nursing
• • Absence of cranial symptoms related to GCA (e.g., only large vessel GCA)