Role of Coagulation, Inflammation and Vessels in Chronic Liver Disease

Launched by ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS · May 9, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how certain factors, like blood clotting, inflammation, and blood vessel changes, affect chronic liver diseases. Chronic liver diseases are serious conditions that can lead to many health problems and significantly impact a person’s quality of life. By better understanding these factors, researchers hope to improve how these diseases are managed and treated, benefiting both patients and the healthcare system.

If you or someone you know has chronic liver disease and is over 18 years old, you might be eligible to participate in this study. To qualify, you need to have a confirmed diagnosis of chronic liver disease or cirrhosis, which might be determined through a liver biopsy, specific imaging tests, or other clinical evaluations. Participants will be asked to provide blood samples, and those without liver disease may also be included as a comparison group. It’s important to note that certain individuals, such as pregnant women or those with recent surgeries, will not be eligible to ensure the safety and accuracy of the study. Overall, this research aims to shed light on important aspects of liver disease to improve patient care.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• Patients with chronic liver disease:
• • Patients over 18 years of age Patients affiliated with a social security plan or entitled to receive benefits Patients with chronic liver disease or cirrhosis whose diagnosis is based on one or more of the following
• • Liver biopsy showing chronic liver disease or cirrhosis
• • Liver elastography by Fibroscan® assessing the elasticity of the liver at more than 10 kpa
• • Combination of clinical, biological and imaging criteria characteristic of chronic liver disease (signs of portal hypertension, liver failure and liver dysmorphia in a patient with at least one risk factor for chronic liver disease)
• • Controls without liver disease Patients 18 years of age with no known liver disease Patients who have had blood drawn in the hospital prior to surgery (pre-operative work-up as part of the care process).
• Exclusion Criteria:
• Common non-inclusion criteria for patients with chronic liver disease and controls without liver disease will be as follows:
• • Pregnant or lactating women
• • Protected populations: persons under guardianship, under curatorship or safeguard of justice
• • Patient under AME
• • Patient who has not signed a consent form
• • Recent surgery before the blood test (\< 2 weeks)
• • Transfusion of blood products (packed red blood cells, platelet concentrates, fresh frozen plasma, etc.) recently (\< 2 weeks)
• • Use of medication that interferes with hemostasis
• • Active extra-hepatic cancer or cancer less than 5 years old
• • Organ transplantation (liver, kidney, lung, heart)