dTDI During a SBT to Predict Extubation Failure in Preterm Infants

Launched by WANG JIANHUI · May 18, 2023

Keywords

ClinConnect Summary

This clinical trial is looking at how well a special test can predict if premature infants will be able to breathe on their own after being on a ventilator. When babies are born too early, sometimes they need help breathing from a machine, and it’s important to know when they are ready to try breathing without it. The study will measure how well the muscles that help with breathing are working during a test where the baby tries to breathe on their own for a short time. This might help doctors understand who is ready for extubation, which is the process of removing the breathing machine.

To participate, infants must be born before 32 weeks of pregnancy and have been on the ventilator for at least two days. They also need to meet certain medical conditions that show they might be ready to breathe without help. If you have a premature baby who meets these criteria, you will be asked to give permission for them to join the study. Throughout the trial, parents and guardians will be informed about what the baby is experiencing, and the research team will closely monitor their progress. This study is currently looking for participants, so it’s a good opportunity for families interested in helping improve care for premature infants.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • premature infants with gestational age \<32 weeks and supported by invasive mechanical ventilation ≥48 hours
• • All the indications for extubation are met：cough or vomiting due to spontaneous breathing and sputum aspiration; ventilator parameters in recent 24 hours: MAP \< 8cmH2O, RR \< 30 times/min, FiO2 \< 30%; Arterial blood gas: pH \> 7.25, (PaCO2\< 60mmHg, BE \< 8mmol/L, oxygen saturation \> 90%
• • a successful SBT
• • parents or legal guardians sign informed consent to attend this study
• Exclusion Criteria:
• • accidental extubation
• • chest CT or bronchoscopy during hospitalization indicated congenital airway dysplasia
• • complex congenital heart disease
• • congenital metabolic diseases, neuromuscular diseases
• • severe brain injury
• • surgical mechanical ventilation
• • give up before extubation;
• • pneumothorax or pleural effusion
• • no consent is signed