Using Indoor Air Filtration to Slow Atherothrombosis Progression in Adults With Ischemic Heart Disease History

Launched by UNIVERSITY OF SOUTHERN CALIFORNIA · May 15, 2023

Keywords

ClinConnect Summary

This clinical trial is studying whether using air filters in homes can help slow down the progression of heart-related issues in adults who have a history of ischemic heart disease, which is a condition caused by reduced blood flow to the heart. The researchers believe that by reducing indoor air pollution, specifically tiny particles known as PM2.5, they can improve heart health. The trial is currently recruiting participants who are between 65 and 84 years old, weigh at least 110 pounds, and have not smoked for the past year. Participants need to live in Los Angeles County and should have stable heart health for the past six months.

If you join this study, you'll be part of a double-blind trial, meaning neither you nor the researchers will know if you're using an air filter or a placebo (a device that doesn't actually filter air). This helps ensure that the results are fair and unbiased. Participants will also have their health monitored throughout the trial. It's important to note that those with specific conditions, like certain types of cancer or nervous system diseases, as well as those living in homes already equipped with air filters, won't be eligible to participate. This study aims to help improve understanding of how better indoor air quality might support heart health in older adults.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age between 65 and 84 years old;
• • Weight ≥ 110 pounds;
• • Nonsmokers for at least 1 year;
• • Have ischemic heart disease history, clinically stable for 6 months, without any deterioration in symptoms or episodes of angina based on past electronic medical records;
• • Both English and Spanish speaking participants will be included in the recruitment;
• • Live in the Los Angeles County.
• Exclusion Criteria:
• • Have history of degenerative disease of the nervous system such as dementia and Alzheimer's;
• • Currently have active cancer treatments;
• • The residential house has already had HEPA filters;
• • Participants will move out from the current residential address in the next 2 years;
• • Participants will spend more than 1 month living outside the primary home;
• • Have any health conditions that prohibit collecting health and covariate data and biospecimens;
• • Participants' residential houses are not feasible for setting up air purifiers and air pollutants monitors.