Influence of Β-hydroxy Β-methyl Butyrate (HMB)supplementation on Post-operative Muscle Mass and Function in Female Athletes

Launched by UNIVERSITY OF KANSAS MEDICAL CENTER · May 18, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how a nutritional supplement called calcium-β-hydroxy-β-methylbutyrate (caHMB) affects muscle mass and function in female athletes who are recovering from knee surgery, specifically for injuries to the anterior cruciate ligament (ACL). The researchers want to find out if taking this supplement, in addition to standard rehabilitation practices, can help these athletes maintain their muscle strength and size during their recovery process. They will recruit about 30 women aged 18 to 35 who have recently been injured and plan to have surgery.

Participants will be randomly assigned to receive either the caHMB supplement or a placebo (a non-active substance) during their rehabilitation. They will be monitored at different stages: before surgery, two weeks after, and every six weeks until they are cleared to return to sports. Throughout the study, their muscle size and strength will be measured, and they will also keep daily logs of their nutrition and activities. This research aims to support better recovery strategies for female athletes who face challenges related to knee injuries.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • 1. Participant has provided written and dated informed consent to participate in the study.
• • 2. Participant is biological female between 18 and 35 years of age, inclusive.
• • 3. Participant intends to complete postoperative rehabilitation at affiliated physical therapy clinic.
• Exclusion Criteria:
• • 1. Participant is currently consuming nutritional supplements or has recently (regularly) consumed nutritional supplements, other than multivitamins and minerals in \<9 weeks prior to participation.
• • 2. Participant currently suffers from a sleep disorder and/or has a known history of (or is currently being treated for) clinical depression, eating disorder(s) or any other psychiatric condition(s) that might limit natural recovery from substantial injury.
• • 3. Participant has a history of orthopedic injury or surgery within the last year in the non-operative limb that may prevent them from completing the study procedures.
• • 4. Participant has history of previous injury or surgery in the operative limb.
• • 5. Participant has implants, hardware, devices, or other non-removable metal material in the body that would limit the accuracy of body composition assessments within the measurement area.
• • 6. Participant is participating in another clinical trial or has received an investigational product within thirty days prior to enrollment.
• • 7. Participant has a known allergy or sensitivity to any ingredient in the test product/s.
• • 8. Participant is pregnant as confirmed by a urine sample and hCG test.