The Optimal Route of Fecal Microbiota Transplantation for Irritable Bowel Syndrome

Launched by TURKU UNIVERSITY HOSPITAL · May 22, 2023

Keywords

ClinConnect Summary

This clinical trial is looking to find the best way to perform a fecal microbiota transplant (FMT) for people with Irritable Bowel Syndrome (IBS). The researchers want to compare two different methods of delivering the transplant: one through the upper part of the gut (using a technique called duodenogastroscopy) and the other through the lower part of the gut (using a method called colonoscopy). They will collect stool samples and ask participants about their symptoms to see which method leads to better symptom relief.

To join the study, participants need to be between 18 and 70 years old, speak Finnish, and have moderate to severe IBS symptoms. Some individuals may not be eligible if they are pregnant, have recently taken antibiotics or probiotics, or have other medical conditions that could cause similar gastrointestinal (GI) symptoms. Those who qualify will have the chance to help researchers understand more about IBS and potentially improve treatment options for themselves and others in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adult
• • 18-70 years
• • known of Finnish language
• • IBS, (new or old diagnosis according to Roma III or IV criteria), all subtypes
• • Informed consent
• • Moderate to severe IBS symptoms, IBS-SSS \> 175
• Exclusion Criteria:
• • Pregnancy
• • Antibiotic or probiotic treatment, on-going or previous month
• • Abuse of drugs, alcohol or medications
• • Other diagnosis besides IBS causing the GI symptoms, such as IBD, microscopic colitis or bile acid diarrhea