Propofol Versus Dexmedetomidine on the Incidence of Postoperative Nausea and Vomiting

Launched by CAIRO UNIVERSITY · May 16, 2023

Keywords

ClinConnect Summary

This clinical trial is looking at how two different medications—propofol and dexmedetomidine—affect the likelihood of experiencing nausea and vomiting after surgery. Postoperative nausea and vomiting (PONV) can delay recovery and make patients uncomfortable, so finding effective ways to manage this issue is important. The study specifically focuses on patients aged 18 to 60 who are undergoing a procedure called ureteroscopy and have multiple risk factors for PONV, such as being female or having a history of nausea after previous surgeries.

To participate in this trial, potential candidates must meet certain criteria. They should be scheduled for a ureteroscopic procedure and have a few specific risk factors for PONV. However, individuals with certain health conditions or allergies to the medications being studied, as well as those who have had anti-nausea medications recently, will not be eligible. Participants in the study will receive either propofol or dexmedetomidine during their procedure and will be monitored for any nausea or vomiting afterward. This research aims to help improve recovery experiences for patients by finding out which medication works better to prevent PONV.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients aged 18 to 60 years
• • ASA physical status I-II
• • Scheduled for ureteroscopic procedure
• • With more than one Risk factor for PONV (female, history of PONV, non-smoking).
• Exclusion Criteria:
• • Patients with contraindications for spinal anesthesia including infection at the injection site, bleeding diathesis, known left ventricular outflow obstruction, hypovolemia, and increased intracranial pressure.
• • History of allergy or hypersensitivity to propofol or dexmedetomidine.
• • Gastrointestinal diseases e.g. gastroenteritis and gastric ulcers, ear diseases e.g. infections of middle and inner ear, liver cirrhosis.
• • Those who have received antiemetic drugs within 48 hours before surgery.
• • Operations lasting more than two hours.
• • The patient's unwillingness.