A Study of Intravenous Acetaminophen for Small Bowel Obstruction

Launched by MAYO CLINIC · May 18, 2023

Keywords

ClinConnect Summary

This clinical trial is looking at how effective intravenous (IV) acetaminophen is for managing pain in patients who have a small bowel obstruction, compared to the usual treatment with opioid medications. A small bowel obstruction happens when something blocks the intestine, causing pain and preventing food and fluids from passing through. The study aims to see if using IV acetaminophen can provide better pain relief without some of the side effects that come with opioids.

To join this study, participants need to be adults aged 65 to 74 who have been diagnosed with a small bowel obstruction and are experiencing abdominal pain. They also need to be on a diet where they cannot eat or drink anything by mouth. However, certain individuals cannot participate, such as those with liver problems, those who are already on opioids, or anyone who cannot provide consent. If eligible, participants can expect to receive either the IV acetaminophen or the standard opioid treatment while their condition is being monitored closely. This trial is currently active but not recruiting new participants at this time.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Small bowel obstruction diagnosed by radiographic study; and
• • Abdominal pain on admission.
• • Nothing per mouth diet.
• • The ability to give appropriate consent or have an appropriate representative available to do so.
• Exclusion Criteria:
• • Known liver failure or cirrhosis.
• • Acetaminophen toxicity on admission.
• • Known acetaminophen allergy.
• • Alcohol intoxication on admission.
• • History of substance abuse.
• • Creatinine clearance \< 30 (or Creatinine level \> 2).
• • Liver transplant recipients.
• • Ileus on admission.
• • Admitted for surgical intervention for SBO.
• • Admitted for venting Gastric tube placement.
• • On chronic opioid therapy (defined as use of opioid on daily or near daily basis within previous 45 days (both long acting and short acting).
• • Presentation without abdominal pain on admission.
• • Already hospitalized for other reasons and develop SBO while at the hospital.
• • Pregnant women.
• • Unable to provide informed consent.