Digital Accessible Remote Olfactory Mediated Health Assessments for Preclinical AD

Launched by MASSACHUSETTS GENERAL HOSPITAL · May 19, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how our sense of smell might help in identifying early signs of memory-related conditions, such as Mild Cognitive Impairment and other cognitive concerns. Researchers want to find out if a special smell test, called the AROMHA Brain Health Test, can act as an early warning sign for neurodegenerative disorders, which are illnesses that affect the brain. The test will take about 45 minutes and involves participants smelling different scents and answering questions about what they experience.

To participate, you need to be between 18 and 100 years old and have a diagnosis of subjective cognitive concerns, mild cognitive impairment, or be a healthy individual for comparison. However, if you have certain respiratory conditions, are currently sick, or have severe cognitive issues that might make it hard for you to do the test, you may not be able to join. It's important to note that participants will not receive their test results, but your involvement could help researchers create a simple and effective tool for diagnosing memory-related issues in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • A clinical or research consensus diagnosis of the patient's condition or control status.
• • Individuals that are at least 18 years of age at the time of enrollment.
• • Individuals that are no older than 100 years of age at the time of enrollment.
• Exclusion Criteria:
• • Primary pulmonary disease such as severe emphysema or asthma not under good medical control.
• • Current sinusitis, common cold, upper respiratory infection, or nasal polyps.
• • Current or recent (past 6 months) alcohol or substance dependence. A prior history of alcohol or substance abuse will not be grounds for exclusion.
• • Pregnancy.
• • Severe cognitive dysfunction that would preclude completion of the olfactory testing.
• • An adverse reaction to fragrances (ie. they trigger a severe asthmatic attack or nausea).