Switching Individuals in Treatment for Opioid Use Disorder Who Smoke Cigarettes to the SREC

Launched by MASSACHUSETTS GENERAL HOSPITAL · May 30, 2023

Keywords

ClinConnect Summary

This clinical trial is exploring whether switching from regular cigarettes to a special research e-cigarette (called SREC) can help adults who are receiving treatment for opioid use disorder and are also daily smokers. The study aims to see if using the SREC is a good option for those who are not ready to quit smoking right now. Researchers will look at how many cigarettes people smoke each day, measure certain health markers, and check for any withdrawal symptoms or health effects from using the e-cigarette over a period of time.

To be eligible for this trial, participants must be at least 18 years old, smoke at least 10 cigarettes a day, and not be planning to quit smoking in the next month. They should also be stable on buprenorphine treatment for opioid use disorder for at least three months. During the study, 40 participants will be randomly assigned to either start using the SREC right away or wait eight weeks before receiving it. Throughout the study, participants will be monitored for a total of 12 to 20 weeks, depending on their group. This trial is currently recruiting participants at Massachusetts General Hospital-affiliated clinics.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 18 years of age
• • Report daily cigarette smoking (\>=10 cigarettes per day in the past week)
• • Not ready to quit smoking (not planning to quit in the next 30 days)
• • Willing to try e-cigarettes
• • In stable buprenorphine (BUP) treatment for opioid use disorder at an Massachusetts General Hospital-affiliated primary care clinic (in treatment for \>=3 months without changes in BUP dose in the past 2 weeks and planning to remain on current BUP treatment for \>=3 months).
• Exclusion Criteria:
• • Pregnant or breastfeeding
• • Using non-cigarette nicotine or tobacco products (e.g., e-cigarettes, cigarillos) recently (\>3 days in past 30 days)
• • Report past 30-day use of behavioral or pharmacologic smoking cessation aids
• • Deemed inappropriate for participation by their OUD provider
• • Have an unstable psychiatric (e.g., past month suicidal ideation, active psychosis) or medical condition (e.g., life expectancy \<1 year).