The Effect of Intra-sinus Application of Betamethasone Dipropionate Nasal Cream on Patients with Chronic Rhinosinusitis Post Functional Endoscopic Sinus Surgery (FESS)

Launched by OTICARA AUSTRALIA PTY LTD · May 22, 2023

Keywords

ClinConnect Summary

This clinical trial is investigating the effects of a nasal cream called Betamethasone Dipropionate on patients with chronic rhinosinusitis (CRS) who have recently undergone a specific type of sinus surgery known as functional endoscopic sinus surgery (FESS). The goal is to determine if a single application of this cream can help improve symptoms and enhance recovery. The trial is currently looking for participants aged between 18 and 80 who have been diagnosed with CRS and have had surgery at least six months prior. They should also have some visible nasal polyps, which are growths that can block the sinuses.

Eligible participants can expect to undergo a thorough screening process to confirm their condition and ensure they meet all necessary criteria. This includes having a certain level of disease severity and being in good overall health. If chosen to participate, they will receive the nasal cream applied directly to their sinuses and will be monitored for any side effects and improvements in their symptoms. It’s important to note that individuals with certain medical conditions, like diabetes or recent use of specific medications, will not be able to take part in this study. Participants will also need to provide informed consent, meaning they agree to take part in the trial and understand what it involves.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adult patients with a clinically confirmed diagnosis of CRS by an otolaryngologist (ENT) undergoing maximal medical therapy as part of their standard of care.
• • Having undergone functional endoscopic sinus surgery (FESS) at least 6 months prior to enrolment.
• • For each nostril, an endoscopic nasal polyp score of 0, 1, or 2 out of a maximum score of - (where 0= No polyps, 1= small polyps in the middle meatus not reaching below the inferior border of the middle turbinate , 2= nasal polyps reaching below the border of the middle turbinate, 3= large nasal polyps reaching the lower border of the inferior turbinate or nasal polyps medial to the middle turbinate, 4= large nasal polyps causing almost complete obstruction of the inferior nasal cavity) (Gevaert et al, 2023).
• • Visible middle turbinates and access to the ethmoid sinuses for dosing as established via endoscopic examination.
• • Participants must have a \> 2 on the disease severity visual analogue scale (VAS) at screening and pre-treatment.
• • Body weight: A minimum body weight \>=40 kilograms (kg) and a BMI of ≤ 39 at the screening visit.
• • Individuals of childbearing potential must use adequate birth control methods and not plan to get pregnant during the study.
• • Informed consent: Willingness to give written informed consent and willingness to participate in and comply with the study.
• • Age ≥18 but \<80 years.
• Exclusion Criteria:
• • Subjects with known hypersensitivity or contraindications to betamethasone dipropionate, mometasone, or topical anaesthesia.
• • Subjects with sino-nasal abnormalities, disease, or implanted devices that prevents the application of the therapy.
• • Previous enrolment in this study.
• • Subjects currently receiving systemic corticosteroid or have received systemic corticosteroid in the prior 4 weeks or receiving biologic therapy.
• • Subjects with a history of glaucoma or cataracts or have an abnormal intraocular pressure (IOP) at screening or pre-treatment (abnormal IOP is defined as greater than 21 mm Hg).
• • Subjects with acute sinusitis.
• • Subjects with known immunodeficiency.
• • Subjects with diabetes (Type 1).
• • Subjects with cystic fibrosis.
• • Pregnant subjects or subjects trying to get pregnant or currently lactating as the effect on human pregnancy is unknown.
• • Subjects who are unable to give an informed consent because of mental illness, dementia or communication difficulties.
• • Subjects with a Cushing's disease diagnosis within the previous 12 months.
• • Severe septal deviation and or previous total resection of the middle turbinate.
• • Any lab abnormality or underlying medical condition which, in the Investigator's opinion, should exclude the participant.
• • Subjects who are unlikely to comply with study procedures, restrictions and requirements as determined by the investigator.