HPV Self-testing in Transgender Individuals

Launched by QUEEN MARY UNIVERSITY OF LONDON · May 22, 2023

Keywords

ClinConnect Summary

**Summary of the Clinical Trial: HPV Self-Testing in Transgender Individuals**

This clinical trial is exploring how common the human papillomavirus (HPV) is among transgender individuals and how effectively it can be detected using self-sampling methods. HPV is a virus that can lead to serious health issues, including certain types of cancer. The study aims to understand if transgender people are at a higher risk for HPV and related cancers, especially since they may not get regular screenings like others. Participants will collect samples from different parts of their bodies, including the vagina and anus, and provide a urine sample, as well as use mouthwash. Transgender men will also have a swab taken by a healthcare provider for routine cervical screening.

To participate in this study, you need to identify as transgender or non-binary and meet certain age and health criteria. For example, transgender men must be between 25 and 65 years old, have an intact cervix, and have used testosterone therapy in the past year. Transgender women must be 18 or older and have had surgery to create a vagina at least one year ago. Participants will also complete an online survey to share their thoughts on self-sampling compared to traditional testing done by a clinician. This research is important as it could help improve screening practices and overall health for transgender individuals.

Gender

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Eligibility criteria

• Inclusion criteria for trans men and non-binary adults with a cervix:
• • Identify as transgender or non-binary
• • Be between 25 - 65 years of age
• • Be registered with a general practitioner
• • Have an intact cervix
• • Have used testosterone therapy within the last year
• • Be willing, and able to understand and consent to study procedures
• Inclusion Criteria for trans women and non-binary adults :
• • Identify as transgender or non-binary
• • Be 18 years of age or older
• • Have undergone vaginoplasty by any method at least 1 year ago
• • Be willing, and able to understand and consent to study procedures
• Exclusion Criteria:
• • Have a variation of sex characteristics (also known as a disorder of sex development)
• • Have an allergy to any of the ingredients in the oral rinse (Scope)
• • Be diagnosed with, or under investigation for, an inflammatory bowel disease (e.g., ulcerative colitis, Crohn's disease). This does not include irritable bowel syndrome - participants with this are eligible to enroll.
• • Be a member of a vulnerable population, which includes pregnant people, fetuses, children, prisoners, or anyone unable to independently offer consent.