Inuit and Cold Exposure

Launched by STIG ANDERSEN · May 22, 2023

Keywords

ClinConnect Summary

**Trial Summary: Inuit and Cold Exposure**

This clinical trial is studying a special type of fat in our bodies called brown adipose tissue (BAT), which helps us stay warm by producing heat without shivering. Scientists are particularly interested in how cold exposure activates this tissue, especially in people living in cold regions like the Arctic. They want to learn more about how BAT works in Greenlanders and non-Greenlanders, as some populations may have unique genetic traits that help them adapt to cold temperatures and utilize BAT more efficiently. Understanding this could lead to new ways to address obesity and related health issues.

To participate in this study, you need to be between 18 and 62 years old and able to give clear consent. However, there are specific health conditions that would prevent you from participating, such as pregnancy, certain medications, and past or current serious health issues like cancer or cardiovascular disease. If eligible, participants can expect to undergo assessments using advanced imaging techniques to measure BAT mass and activity. This is an exciting opportunity to contribute to important research that could improve our understanding of how our bodies handle cold and manage weight.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Ability to give informed consent
• • Ability to follow written and verbal instructions
• Exclusion Criteria:
• • Pregnancy and breastfeeding
• • Alpha- or beta-adrenergic affecting medication.
• • Thyroid dysfunction
• • Liver or kidney disease
• • Treatment for diabetes
• • MODY and TBC1D4
• • Treatment of obesity
• • Cardiovascular disease
• • Cancer within 3 years
• • Mb Renaud
• • Hospitalisation for psychiatric disease
• • Antipsychotic medication
• • Drug abuse within 1-year
• • Alcohol abuse
• • Plasma glucose \> 11 mM
• • BMI \>35 kg/m2
• • Winter swimmer