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Search / Trial NCT05885295

The Imperial Comprehensive Cognitive Assessment in Cerebrovascular Disease (IC3)

Launched by IMPERIAL COLLEGE LONDON · May 30, 2023

Trial Information

Current as of June 25, 2025

Recruiting

Keywords

Dementia Mri Blood Biomarkers Neurofilament Light Amyloid Tau Gfap White Matter Hyper Intensity Micro Bleed Small Vessel Disease Cognitive Impairment Vascular Dementia Stroke Aphasia Neglect

ClinConnect Summary

The Imperial Comprehensive Cognitive Assessment in Cerebrovascular Disease (IC3) trial is studying how to better assess cognitive abilities in patients who have experienced a stroke. Many stroke survivors face challenges with thinking and memory, which can make recovery difficult. This study aims to develop a new digital tool that can help identify these cognitive issues in a simple and effective way, without needing extensive help from healthcare professionals. By understanding these cognitive deficits better, healthcare providers can tailor rehabilitation efforts to those who need it most.

To participate in this trial, individuals must be over 18 years old and have had a confirmed stroke. Participants should be able to focus for about 15 minutes to engage in cognitive testing. However, people with a pre-existing diagnosis of dementia or severe mental health issues may not be eligible. Throughout the study, participants can expect to undergo cognitive assessments, brain imaging, and blood tests to explore new ways to track recovery after a stroke. This research could ultimately help improve care for stroke survivors and enhance their chances of a successful recovery.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Aged \> 18
  • Evidence of confirmed stroke (for patients)
  • Ability to concentrate for 15 minutes at a time to engage with cognitive testing
  • Exclusion Criteria for the main study:
  • Pre-stroke diagnosis of dementia
  • Severe visuo-spatial problems, fatigue, or mental health problems
  • Severe hearing impairment in the presence of reading comprehension impairment
  • Exclusion Criteria for the MRI imaging sub-study:
  • Pregnancy
  • Presence of metal implants
  • Claustrophobia

About Imperial College London

Imperial College London is a world-renowned research institution based in the United Kingdom, recognized for its commitment to advancing medical science and improving patient care through innovative research and clinical trials. With a strong emphasis on interdisciplinary collaboration, Imperial combines expertise across various fields, including medicine, engineering, and business, to drive breakthroughs in healthcare. The institution’s robust clinical trial programs are designed to evaluate new therapies and interventions, ensuring rigorous scientific standards and ethical practices while aiming to translate research findings into tangible benefits for patients and society.

Locations

London, , United Kingdom

Patients applied

0 patients applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported