Shanghai Non-pharmacological Intervention for Mild Cognitive Impairment and Mild Alzheimer's Disease

Launched by RUIJIN HOSPITAL · Jun 2, 2023

Keywords

ClinConnect Summary

This clinical trial is looking at how lifestyle changes can help people with mild cognitive impairment and mild Alzheimer's disease. The researchers want to see if a combination of a special diet, exercise, and mental training can make a difference for patients. This study is being conducted at multiple centers and is currently recruiting participants who are between 60 and 90 years old, have been diagnosed with mild cognitive impairment or mild Alzheimer's disease, and have a good ability to understand and give consent.

To participate, individuals should not have other serious health issues affecting their thinking, like significant brain injuries or other types of dementia. Participants will be closely monitored for at least six months, and they will engage in activities that promote a healthy lifestyle. This trial aims to find out if these lifestyle changes can improve their cognitive abilities and overall well-being, making it a potentially valuable opportunity for those who qualify.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Aged 60-90 years
• • 2. In accordance with the diagnostic criteria for "mild cognitive impairment due to Alzheimer's disease" or "mild Alzheimer's disease" from the National Institutes of Health National Institute on Aging-Alzheimer's Association (NIA-AA) (2011)
• • 3. The Hamilton depression rating scale/17 edition (HAMD) total score≤10
• • 4. Neurological examination: no obvious signs
• • 5. Education: primary school (grade 6) or above and capacity to complete tests for cognitive ability
• • 6. Capacity to give consent
• Exclusion Criteria:
• • 1. Other causes of cognitive decline: cerebrovascular disease, central nervous system infection, Creutzfeldt-Jakob disease, Huntington's and Parkinson's disease, Creutzfeldt-Jakob disease, traumatic brain dementia, other physical and chemical factors (such as drugs, alcohol, CO), systemic disease (hepatic encephalopathy, pulmonary encephalopathy, etc.), intracranial occupation (a subdural hematoma, brain tumor), the endocrine system disease (thyroid disease, parathyroid disease), and vitamins deficiency or any other causes of dementia
• • 2. The history of nervous system diseases, including stroke, optic myelitis, Parkinson's disease, epilepsy, etc
• • 3. Psychiatric patients, including schizophrenia or other mental illnesses, bipolar disorder, major depression, or delirium
• • 4. There are unstable or serious heart, lung, liver, kidney, endocrine, and hematopoietic system diseases, or Poor prognosis because of malignant diseases such as tumors.
• • 5. Vision or hearing problems that lead to poor performance on cognitive tests
• • 6. Two years history of severe alcoholism, and drug abuse
• • 7. Participants who participated in any other trial 30 days prior to their screening visit
• • 8. Contraindication of MRI scanning
• • 9. Special requirements for diet, e.g., allergy to common food or on a special diet due to medical needs
• • 10. Participants who cannot be followed for at least 6 months (due to a health situation or migration)