F18-MHF: Orthopedic Implants-Associated Infection Detection

Launched by EMORY UNIVERSITY · May 25, 2023

Keywords

ClinConnect Summary

This clinical trial is studying a new way to detect infections in knee implants using a special imaging technique called PET scanning. The researchers will inject a small amount of a radioactive substance, known as F-18 MHF, into the bloodstream. This will help them see how the substance gathers around knee implants that are either infected or not infected. By comparing the images, they hope to find out if this method can accurately identify infections in patients with knee replacements.

To participate in this trial, you need to be at least 18 years old and able to give written consent. If you have a knee implant and your doctor suspects an infection, especially if you’re scheduled for surgery to address it, you might be eligible. There is also a group for people who have a knee implant without any complications for at least six months. Participants will lie still while undergoing a PET scan for about 90 minutes, and this process will help researchers learn more about detecting knee implant infections effectively.

Gender

ALL

Eligibility criteria

• • Inclusion Criteria for symptomatic patient cohort
• • Patients must be 18 years of age or older, able to provide written informed consent, and ability to lie still for PET scanning.
• • Suspected knee prosthetic infection at least 2 months after original prosthesis placement and who are scheduled to undergo surgery debridement/removal based on the clinical assessment of the referring surgeon.
• • Elevated CRP and ESR
• Exclusion Criteria for symptomatic patient cohort:
• • Undergoing current or recent antimicrobial therapy (within 1 month)
• • Significant comorbidity such as renal failure, septic shock, uncontrolled diabetes
• • Other clinically likely site of infection
• Inclusion Criteria for asymptomatic cohort:
• • Patients must be 18 years of age or older, able to provide written informed consent and ability to lie still for PET scanning
• • Knee prosthesis in situ without complications for 6 months or longer
• Exclusion Criteria for asymptomatic cohort:
• • Clinical or laboratory suspicion of knee prosthesis infection
• • Recent (within 3 months) or current treatment for infected knee prosthesis
• • Significant comorbidity such as renal failure, septic shock, uncontrolled diabetes