Remimazolam for Postoperative Atrial Fibrillation

Launched by YANGZHOU UNIVERSITY · Jun 5, 2023

Keywords

ClinConnect Summary

**Trial Summary: Remimazolam for Postoperative Atrial Fibrillation**

This clinical trial is looking at a medication called remimazolam to see if it can help prevent a common heart rhythm problem called postoperative atrial fibrillation (POAF) in patients undergoing coronary artery bypass grafting (CABG). POAF can happen after heart surgery and affects about 30% of patients. Remimazolam is a sedative that not only helps patients relax during surgery but may also reduce inflammation, which is linked to the development of POAF. The goal of the study is to find out if using remimazolam during the surgery can lower the chances of developing this condition and how it affects certain stress and inflammation markers in the body.

To participate in this trial, you need to be between 50 and 70 years old with a body mass index (BMI) between 18 and 28. You must be scheduled for elective CABG surgery at a specific hospital in Yangzhou, China, and willing to sign a consent form to join the study. Unfortunately, patients who have emergency surgeries, other types of heart surgeries, or certain health conditions won't be eligible. If you qualify and choose to participate, you'll be part of an important effort to improve care for heart surgery patients, and you can expect to be monitored closely throughout the process to ensure your safety and well-being.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 50-70 years old;
• • BMI 18-28 kg/m2；
• • Selective CABG surgery will be performed at the Yangzhou Institute Heart and Great Vessels, the Affiliated Hospital of Yangzhou University, Yangzhou, China.
• • Patients agree to participate in this study and sign the informed consent form.
• Exclusion Criteria:
• • Emergency surgery;
• • with any other type of cardiac surgery;
• • pre-operative supraventricular arrhythmia;
• • with moderate or severe valve disease before surgery;
• • with a history of chemotherapy or radiotherapy;
• • with a history of thoracic or cardiovascular surgery;
• • diuretics usage before the surgery.