Conventional Versus Left Bundle Branch Pacing in TAVI

Launched by UNIVERSITY MEDICAL CENTRE LJUBLJANA · Jun 5, 2023

Keywords

ClinConnect Summary

This clinical trial, called "Conventional Versus Left Bundle Branch Pacing in TAVI," is looking at how two different types of heart pacing affect patients who have undergone a procedure called transcatheter aortic valve implantation (TAVI). Specifically, it compares traditional pacing methods with a newer technique called left bundle branch pacing. The aim is to see which method better helps the heart recover and function well in patients with weakened heart function, known as reduced left ventricular ejection fraction (LVEF), who need a permanent pacemaker after TAVI.

To participate in this study, patients must need a permanent pacemaker after their TAVI procedure and have a left ventricular ejection fraction below 50%, which means their heart isn't pumping as well as it should. The trial is not yet recruiting participants, but if you meet these criteria and are between the ages of 65 and 74, you may be eligible. Participants can expect to receive either type of pacing during their hospital stay, and the study aims to gather important information about how these methods impact heart recovery over time.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Indication for permanent pacemaker implantation after transcatheter aortic valve implantation (during the same hospitalization)
• • Left ventricular ejection fraction \< 50 %.
• Exclusion Criteria:
• • Unsuccessful TAVI procedure with life expectancy \< 1 year
• • Ischemic cardiomyopathy with interventricular septal fibrosis (at least echocardiographic signs of fibrosis)
• • Severe kidney failure (glomerular filtration rate \< 30 ml/min)
• • Previous permanent pacemaker