Cognitive Training for Cancer Related Cognitive Impairment in Breast Cancer Survivors
Launched by NRG ONCOLOGY · May 31, 2023
Trial Information
Current as of July 26, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is looking at how effective computer-based cognitive training can be for breast cancer survivors who are experiencing problems with their thinking and memory, often referred to as cognitive impairment. The study aims to see if this training can help improve their cognitive abilities and make their daily lives easier. The trial is currently recruiting participants aged 65 to 74 and 36 to 54, regardless of gender, who have had non-metastatic breast cancer (meaning the cancer has not spread) and have completed their initial treatment.
To participate, individuals must agree to the study and have a score that shows they are experiencing some cognitive difficulties. They should be at least 6 months and not more than 5 years post-treatment. It's important that participants can communicate in English or Spanish. However, people with certain medical histories, such as a previous diagnosis of metastatic breast cancer or significant mental health issues, won't be eligible. If you join the study, you can expect to take part in cognitive training exercises and contribute to important research that may help other breast cancer survivors in the future.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • The participant must provide study-specific informed consent prior to any study specific procedures and authorization permitting release of personal health information.
- • The participant must have a first time diagnosis of non-metastatic breast cancer which is Stage I-III.
- • The participant must have a score of less than 12 on the PROMIS Adult v2.0 - Cognitive Function 4a.
- • Participants must be at least 6 months and no more than 5 years (after completion of initial surgery +/- adjuvant chemotherapy/radiation therapy) and targeted therapies (e.g., PARP inhibitors, CDK4/6, or immunotherapy). Participants may still be taking endocrine therapy and/or trastuzumab.
- • The participant must be able to understand, speak, read, and write in English or Spanish.
- Exclusion Criteria:
- • Scoring less than or equal to 3 on the 6-item cognitive screen.
- • Patient Health Questionnaire-2 item (PHQ-2) score of greater than or equal to 3.
- • Definitive clinical or radiologic evidence of metastatic disease.
- • Current or past history of another cancer. Patients with history of only non-melanoma skin cancer or in situ cervical cancer without chemotherapy treatment would be eligible.
- • Previous exposure to chemotherapy treatment for another cancer or due to other medical condition (e.g. methotrexate exposure for treatment of rheumatoid arthritis).
- • Previous central nervous system (CNS) radiation, intrathecal therapy or CNS-involved surgery.
- • Participants with history of stroke, traumatic brain injury, brain surgery, Alzheimer's disease or other dementia.
- • Participants with active substance abuse and/or in treatment for substance abuse, or history of bipolar disorder, psychosis, schizophrenia, ADHD, or learning disability.
- • Participants who are enrolled in an active behavioral intervention (e.g., occupational therapy, physical therapy, etc.) or pharmaceutical intervention or who are in the follow-up phase of a cancer control trial or therapeutic trial that has extensive PRO follow-up after treatment ends. Participants who are enrolled in a therapeutic trial in which they have completed active treatment and require only minimal follow-up monitoring of toxicity and/or survival analysis (cancer-related mortality or all-cause mortality) would be eligible.
- • Hearing impairment unless adequately corrected with hearing aids to be able to hear over the phone for the neuropsychological testing.
About Nrg Oncology
NRG Oncology is a prominent clinical trial sponsor dedicated to advancing cancer research through innovative multi-institutional studies. Comprising a collaborative network of leading academic institutions and community hospitals, NRG Oncology focuses on enhancing patient outcomes by conducting rigorous clinical trials that evaluate new treatment strategies and improve existing therapies. With a commitment to scientific excellence and patient-centered care, the organization plays a vital role in shaping the future of oncology by integrating cutting-edge research with clinical practice, ultimately striving to translate findings into meaningful improvements in cancer care.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Chicago, Illinois, United States
Washington, District Of Columbia, United States
Flint, Michigan, United States
Flint, Michigan, United States
Kalamazoo, Michigan, United States
Edina, Minnesota, United States
Waconia, Minnesota, United States
Peoria, Illinois, United States
Detroit, Michigan, United States
Zion, Illinois, United States
Galveston, Texas, United States
Anchorage, Alaska, United States
Tallahassee, Florida, United States
Oklahoma City, Oklahoma, United States
Des Moines, Iowa, United States
Saint Paul, Minnesota, United States
West Chester, Pennsylvania, United States
Chanute, Kansas, United States
Dodge City, Kansas, United States
Newton, Kansas, United States
Wellington, Kansas, United States
Winfield, Kansas, United States
Kalamazoo, Michigan, United States
Traverse City, Michigan, United States
Lancaster, Ohio, United States
Cincinnati, Ohio, United States
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Mount Vernon, Illinois, United States
Salina, Kansas, United States
Chillicothe, Ohio, United States
Salina, Kansas, United States
Coon Rapids, Minnesota, United States
Urbana, Illinois, United States
Carroll, Iowa, United States
Wichita, Kansas, United States
Ann Arbor, Michigan, United States
Minneapolis, Minnesota, United States
Saint Paul, Minnesota, United States
Shakopee, Minnesota, United States
Willmar, Minnesota, United States
Torrance, California, United States
Council Bluffs, Iowa, United States
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Saint Joseph, Missouri, United States
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Wilmington, Ohio, United States
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Longmont, Colorado, United States
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Peru, Illinois, United States
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Maplewood, Minnesota, United States
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Stillwater, Minnesota, United States
Findlay, Ohio, United States
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Honolulu, Hawaii, United States
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Reidsville, North Carolina, United States
Akron, Ohio, United States
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Cincinnati, Ohio, United States
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Warren, Ohio, United States
Wright Patterson Air Force Base, Ohio, United States
Youngstown, Ohio, United States
East Stroudsburg, Pennsylvania, United States
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Princeton, Illinois, United States
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Houston, Texas, United States
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Harrisburg, Pennsylvania, United States
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Goshen, Indiana, United States
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Marquette, Michigan, United States
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Jefferson City, Missouri, United States
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Meadowbrook, Pennsylvania, United States
Longview, Washington, United States
Roanoke, Virginia, United States
Fresno, California, United States
Merced, California, United States
Modesto, California, United States
Rancho Cordova, California, United States
Roseville, California, United States
South San Francisco, California, United States
Lihue, Hawaii, United States
Fruitland, Idaho, United States
Meridian, Idaho, United States
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Twin Falls, Idaho, United States
Overland Park, Kansas, United States
Farmington Hills, Michigan, United States
Kansas City, Missouri, United States
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Columbus, Ohio, United States
Columbus, Ohio, United States
Portsmouth, Ohio, United States
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Edmonds, Washington, United States
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Springfield, Illinois, United States
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Mclean, Virginia, United States
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West Columbia, South Carolina, United States
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Clive, Iowa, United States
West Des Moines, Iowa, United States
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Caro, Michigan, United States
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Clarkston, Michigan, United States
Clarkston, Michigan, United States
East China Township, Michigan, United States
Flint, Michigan, United States
Flint, Michigan, United States
Grosse Pointe Woods, Michigan, United States
Grosse Pointe Woods, Michigan, United States
Macomb, Michigan, United States
Marlette, Michigan, United States
Pontiac, Michigan, United States
Pontiac, Michigan, United States
Pontiac, Michigan, United States
Saginaw, Michigan, United States
Sterling Heights, Michigan, United States
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Warren, Michigan, United States
Warren, Michigan, United States
Warren, Michigan, United States
West Branch, Michigan, United States
Ypsilanti, Michigan, United States
Grove City, Ohio, United States
West Chester, Ohio, United States
Lewisburg, Pennsylvania, United States
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Manahawkin, New Jersey, United States
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Aberdeen, Washington, United States
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Peoria, Illinois, United States
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Carbondale, Illinois, United States
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Effingham, Illinois, United States
Mattoon, Illinois, United States
O'fallon, Illinois, United States
Yorkville, Illinois, United States
Brighton, Michigan, United States
Brownstown, Michigan, United States
Canton, Michigan, United States
Chelsea, Michigan, United States
Clinton Township, Michigan, United States
Novi, Michigan, United States
West Bloomfield, Michigan, United States
Ypsilanti, Michigan, United States
Maple Grove, Minnesota, United States
Wyoming, Minnesota, United States
Sainte Genevieve, Missouri, United States
Sullivan, Missouri, United States
Centerville, Ohio, United States
Cincinnati, Ohio, United States
Dayton, Ohio, United States
Findlay, Ohio, United States
Findlay, Ohio, United States
Franklin, Ohio, United States
Greenville, Ohio, United States
Clackamas, Oregon, United States
Mount Vernon, Washington, United States
Seattle, Washington, United States
Glenview, Illinois, United States
Highland Park, Illinois, United States
Ames, Iowa, United States
Auburn, New York, United States
Syracuse, New York, United States
Pottsville, Pennsylvania, United States
Lutherville, Maryland, United States
Richmond, Virginia, United States
Bakersfield, California, United States
Dublin, California, United States
Fresno, California, United States
Sacramento, California, United States
San Rafael, California, United States
Skokie, Illinois, United States
Norton Shores, Michigan, United States
Monticello, Minnesota, United States
Columbus, Mississippi, United States
Grenada, Mississippi, United States
New Albany, Mississippi, United States
Oxford, Mississippi, United States
Southhaven, Mississippi, United States
Gaffney, South Carolina, United States
Greer, South Carolina, United States
Union, South Carolina, United States
Memphis, Tennessee, United States
League City, Texas, United States
Eau Claire, Wisconsin, United States
Honolulu, Hawaii, United States
London, Kentucky, United States
Port Townsend, Washington, United States
'Aiea, Hawaii, United States
Washington, District Of Columbia, United States
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Ashland, Wisconsin, United States
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Selinsgrove, Pennsylvania, United States
Peoria, Arizona, United States
Phoenix, Arizona, United States
Winter Haven, Florida, United States
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North Kansas City, Missouri, United States
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Santa Maria, California, United States
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Boulder, Colorado, United States
Tawas City, Michigan, United States
Perrysburg, Ohio, United States
Royal Oak, Michigan, United States
Royal Oak, Michigan, United States
Royal Oak, Michigan, United States
Royal Oak, Michigan, United States
Sterling Heights, Michigan, United States
Troy, Michigan, United States
Troy, Michigan, United States
Seattle, Washington, United States
Surprise, Arizona, United States
Bayamon, , Puerto Rico
Dekalb, Illinois, United States
Kensington, Maryland, United States
Beavercreek, Ohio, United States
Stevens Point, Wisconsin, United States
Bayamon, , Puerto Rico
Manati, , Puerto Rico
Winchester, Virginia, United States
Arroyo Grande, California, United States
Plant City, Florida, United States
Saint Petersburg, Florida, United States
Morehead, Kentucky, United States
Aitkin, Minnesota, United States
Deer River, Minnesota, United States
Hibbing, Minnesota, United States
Sandstone, Minnesota, United States
Virginia, Minnesota, United States
Hazleton, Pennsylvania, United States
Collierville, Tennessee, United States
Ashland, Wisconsin, United States
Stockton, California, United States
Honolulu, Hawaii, United States
Ballwin, Missouri, United States
Washington, Missouri, United States
Gilbert, Arizona, United States
Denver, Colorado, United States
Fort Dodge, Iowa, United States
Royal Oak, Michigan, United States
Redmond, Oregon, United States
Royal Oak, Michigan, United States
Mechanicsville, Virginia, United States
Farrell, Pennsylvania, United States
Lake Forest, Illinois, United States
Marquette, Michigan, United States
Detroit Lakes, Minnesota, United States
Fosston, Minnesota, United States
Park Rapids, Minnesota, United States
Jamestown, North Dakota, United States
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Springfield, Ohio, United States
Centennial, Colorado, United States
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Fort Myers, Florida, United States
Dixon, Illinois, United States
Washington, Illinois, United States
Farmington, Missouri, United States
Redwood City, California, United States
Santa Rosa, California, United States
Colorado Springs, Colorado, United States
Englewood, Colorado, United States
Peabody, Massachusetts, United States
Burnsville, Minnesota, United States
York, Pennsylvania, United States
Richmond, Virginia, United States
San Juan, , Puerto Rico
Alma, Michigan, United States
Alpena, Michigan, United States
Gladwin, Michigan, United States
Princeton, Minnesota, United States
Carmichael, California, United States
'Aiea, Hawaii, United States
'Ewa Beach, Hawaii, United States
Honolulu, Hawaii, United States
Kalamazoo, Michigan, United States
Baxter, Minnesota, United States
Ely, Minnesota, United States
International Falls, Minnesota, United States
Moose Lake, Minnesota, United States
Greensboro, North Carolina, United States
Cranberry Township, Pennsylvania, United States
Monroeville, Pennsylvania, United States
Midlothian, Virginia, United States
Goodyear, Arizona, United States
Frederick, Maryland, United States
Newnan, Georgia, United States
Neenah, Wisconsin, United States
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Torrance, California, United States
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Napa, California, United States
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Spooner, Wisconsin, United States
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Nampa, Idaho, United States
Alton, Illinois, United States
Springfield, Illinois, United States
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Toledo, Ohio, United States
Toledo, Ohio, United States
Santa Monica, California, United States
Lexington, Kentucky, United States
Phoenix, Arizona, United States
Safety Harbor, Florida, United States
Normal, Illinois, United States
Kansas City, Missouri, United States
Cumberland, Maryland, United States
Des Moines, Iowa, United States
Kennewick, Washington, United States
Mount Sterling, Kentucky, United States
Cameron Park, California, United States
Wyoming, Michigan, United States
Grand Rapids, Michigan, United States
Muskegon, Michigan, United States
Troy, Ohio, United States
Grove City, Ohio, United States
Meadowbrook, Pennsylvania, United States
Pontiac, Michigan, United States
Pittsburg, Kansas, United States
Ann Arbor, Michigan, United States
Brighton, Michigan, United States
Chelsea, Michigan, United States
Centralia, Illinois, United States
Richmond, Virginia, United States
Paducah, Kentucky, United States
Pittsburgh, Pennsylvania, United States
Mount Pleasant, Michigan, United States
San Juan, , Puerto Rico
Danville, Illinois, United States
New Albany, Ohio, United States
Orland Park, Illinois, United States
Boone, Iowa, United States
Fort Dodge, Iowa, United States
Jefferson, Iowa, United States
Marshalltown, Iowa, United States
Ames, Iowa, United States
Merced, California, United States
Canton, Michigan, United States
Minocqua, Wisconsin, United States
Asheboro, North Carolina, United States
Florham Park, New Jersey, United States
Osage Beach, Missouri, United States
Glenview, Illinois, United States
Grayslake, Illinois, United States
Ankeny, Iowa, United States
Sunset Hills, Missouri, United States
Marysville, Ohio, United States
Niles, Michigan, United States
Reed City, Michigan, United States
Saint Joseph, Michigan, United States
O'fallon, Illinois, United States
Des Moines, Iowa, United States
Clive, Iowa, United States
Woodbridge, Virginia, United States
Lansing, Michigan, United States
Scottsdale, Arizona, United States
Scottsdale, Arizona, United States
Carmichael, California, United States
Phoenix, Arizona, United States
Tempe, Arizona, United States
Grand Rapids, Michigan, United States
Hays, Kansas, United States
Saint Joseph, Michigan, United States
Jefferson City, Missouri, United States
Pontiac, Michigan, United States
Wilmington, Ohio, United States
Silverdale, Washington, United States
Dayton, Ohio, United States
Grand Rapids, Michigan, United States
Royal Oak, Michigan, United States
Walnut Creek, California, United States
Dearborn, Michigan, United States
Farmington Hills, Michigan, United States
Troy, Michigan, United States
Saginaw, Michigan, United States
Tawas City, Michigan, United States
Paducah, Kentucky, United States
Camillus, New York, United States
Detroit, Michigan, United States
Grosse Pointe Woods, Michigan, United States
Grosse Pointe Woods, Michigan, United States
Macomb, Michigan, United States
Warren, Michigan, United States
Flint, Michigan, United States
Kalamazoo, Michigan, United States
Warren, Michigan, United States
East China Township, Michigan, United States
Macomb, Michigan, United States
Warren, Michigan, United States
Frederick, Maryland, United States
Olathe, Kansas, United States
Grosse Pointe Woods, Michigan, United States
Westminster, Colorado, United States
Mount Vernon, Illinois, United States
Ankeny, Iowa, United States
Clive, Iowa, United States
Des Moines, Iowa, United States
Des Moines, Iowa, United States
Waukee, Iowa, United States
Rolla, Missouri, United States
Asheboro, North Carolina, United States
Cape Girardeau, Missouri, United States
Union, South Carolina, United States
Winchester, Massachusetts, United States
Stoneham, Massachusetts, United States
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported