A Novel Integrative Non-invasive Embryo Selection Approach for IVF Based on MK-RS Analysis

Launched by CHINESE UNIVERSITY OF HONG KONG · May 31, 2023

Keywords

ClinConnect Summary

This clinical trial is exploring a new and innovative way to select embryos during in vitro fertilization (IVF) treatments. The study combines advanced technologies, such as artificial intelligence (AI) and a method called Raman spectroscopy, to improve the accuracy of embryo selection. The goal is to help increase the chances of a successful pregnancy by identifying the healthiest embryos more effectively. Participants in this trial will be divided into two groups: one will have their embryos selected using the new AI-enhanced methods, while the other group will rely on traditional evaluation techniques.

To be eligible for this trial, patients must be undergoing their first, second, or third cycle of IVF or intracytoplasmic sperm injection (ICSI), and they need to have at least three normally fertilized embryos available. Participants and their partners should also be willing to sign consent forms. Throughout the study, patients can expect regular monitoring and assessments to compare the success rates of the two embryo selection methods. This trial is taking place at The Assisted Reproductive Technology Unit of The Chinese University of Hong Kong, Prince of Wales Hospital, and aims to provide valuable insights that could help many couples facing reproductive challenges.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Patients undergoing IVF/ ICSI treatment
• • 2. Patients receiving the first, second or third IVF/ICSI treatment cycle
• • 3. Patients and their partners willing to sign the informed consent agreement
• • 4. Patients having at least three normal fertilised embryos on the day of the fertilization check
• • 5. Consecutive women undergoing IVF treatment
• • 6. Patients planning to use a time-lapse incubator for embryo culture
• Exclusion Criteria:
• • 1. Day one human embryos with blur imaging
• • 2. Large obstructions in the embryo area
• • 3. More than half of the embryo area is blocked by the well or degeneration
• • 4. Patients with more than half of the embryos without sufficient spent culture medium for RS analysis
• • 5. Patients with known genetic diseases