High-resolution Magnetic Resonance Imaging of Intracranial Atherosclerotic Plaques in Ischemic Stroke

Launched by GENERAL HOSPITAL OF SHENYANG MILITARY REGION · Jun 1, 2023

Keywords

ClinConnect Summary

This clinical trial is studying a special imaging technique called High-resolution Magnetic Resonance Imaging (HRMRI) to better understand the causes of ischemic stroke, particularly in patients with a condition known as intracranial atherosclerosis, which is the buildup of plaque in the arteries of the brain. This study aims to create a large database of HRMRI images from patients in China who have experienced a stroke. By examining these images, researchers hope to learn more about the characteristics of the plaques that lead to strokes and improve treatment options.

To be eligible for this study, participants must be at least 40 years old, have had a stroke within the last two weeks, and have a certain level of stroke severity. They should also have a specific type of plaque in their arteries, as determined by HRMRI. This study is open to all genders, and participants can expect to undergo HRMRI scans, which are safe and do not involve surgery. The findings from this research could help develop better prevention strategies for future strokes.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Patient age ≥40 years
• • 2. Time of stroke onset: within 2 week
• • 3. Baseline NIHSS score ≤16
• • 4. Ischemic stroke confirmed by head CT or MRI
• • 5. Premorbid mRS ≤1
• • 6. The degree of stenosis of extracranial arteries including internal carotid artery, vertebral artery on the lesion side ≤50%
• • 7. The culprit plaque or possible culprit plaque with plaque burden of 40% or more found by HRMRI in the proximal part of the middle cerebral artery M1 segment or basilar artery of ipsilateral lesion
• • 8. Signed informed consent
• Exclusion Criteria:
• • 1. Intracranial hemorrhage found by head CT
• • 2. Had a contraindication to MRI,or could not complete required MRI sequences
• • 3. Intracranial tumor, arteriovenous malformation, or aneurysm
• • 4. Comorbidity with any serious diseases and life expectancy is less than one year
• • 5. Pregnancy
• • 6. Patients not suitable for this clinical studies considered by researcher