Relationship Between Lidocaine and Serum Orphanin FQ (N/OFQ)

Launched by SECOND HOSPITAL OF SHANXI MEDICAL UNIVERSITY · Jun 2, 2023

Keywords

ClinConnect Summary

**Clinical Trial Summary: Relationship Between Lidocaine and Serum Orphanin FQ (N/OFQ)**

This clinical trial is looking into how an intravenous injection of lidocaine, a common medication used during surgeries, affects stress responses in patients. Lidocaine is often given to help reduce pain and other unpleasant side effects after surgery, such as nausea and cognitive issues. However, researchers want to better understand how it works in the body, especially regarding a neurotransmitter called Serum N/OFQ, which influences pain and emotions. By studying this, they hope to improve surgical care and help patients feel more comfortable during and after their procedures.

To take part in the trial, you need to be between the ages of 18 and 75 and be scheduled for elective abdominal surgery that lasts about 1 to 2 hours. However, some patients won't be eligible, including those with certain health conditions like severe heart problems, diabetes, or respiratory issues. If you join the study, you can expect to receive lidocaine during your surgery, and researchers will monitor how it impacts your stress levels and recovery. This could lead to better pain management and overall care for future surgical patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • ASA I-II
• • Patients undergoing elective abdominal surgery with anesthesia duration less than 1-2h
• Exclusion Criteria:
• • It is estimated that patients with difficulty in tracheal intubation (poor head and neck mobility, history of airway surgery, history of OSAHS, nail to chin distance\<6cm, Malampati grade 3 and above, mouth opening\<2.5cm, obesity (BMI\>30kg · m-2), etc.)
• • Hypertension patients (clinically diagnosed as hypertension), coronary heart disease patients (with typical symptoms of angina pectoris and exclusion of aortic valve disease, clear history of old myocardial infarction, clear history of acute myocardial infarction)
• • Patients with diabetes and central nervous system diseases
• • Patients with long-term use of sedatives or antidepressants
• • Patients with a history of alcoholism or drug dependence
• • Asthma or reactive airway disease
• • Shock, severe hypotension, severe arrhythmia and other adverse events occurred during the operation