A Novel Imaging Protocol in Use to Identify Lymph Nodes and Organs of Interest

Launched by DANA-FARBER CANCER INSTITUTE · Jun 8, 2023

Keywords

ClinConnect Summary

This clinical trial is exploring a new way to help doctors better see and locate cancerous lymph nodes and organs during surgery for urologic cancers, such as bladder, prostate, testicular, kidney, urethral, and penile cancers. The study will use a combination of advanced imaging techniques, including electromagnetic tracking, laparoscopic imaging, and ultrasound, to make surgeries simpler and more precise. The hope is that this improved visualization will lead to better outcomes for patients, including fewer complications and improved recovery.

To participate in this trial, you need to be at least 18 years old and have a confirmed or suspected diagnosis of cancer in one of the targeted urologic areas. You'll also need to have had certain types of scans recently and be scheduled for a specific type of surgery, like lymph node dissection or organ removal, at Brigham and Women's Hospital. If you join the study, you can expect to undergo the new imaging techniques during your surgery, which may help your doctors perform the procedure more effectively. It’s important to note that certain health conditions might exclude you from participating, so discussing your medical history with the research team will be essential.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Signed written informed consent before any trial-related procedure is undertaken that is not part of the standard patient management
• • Subjects aged ≥ 18 years. Selected patients must have a confirmed or suspected diagnosis of disease in urologic regions of interest, with scheduled confirmatory surgical biopsy.
• • Subjects must have had either of the following scans: CT, PET or MR of acceptable quality at Brigham and Women's Hospital within the past year.
• • Subjects must also be scheduled to undergo lymph node dissection for a urologic cancer or organ removal of any of the following urologic regions of interest: Bladder, Prostate, Testicle, Ureter, Kidney, Urethra, Penis, and Scrotum
• • Subjects must also be scheduled to undergo a laparoscopic lymph node dissection and/or a urologic organ removal within any OR at BWH.
• Exclusion Criteria:
• • Severely impaired renal function with an EGFR \< 30 mL/min/body surface area
• • Evidence of any significant, uncontrolled comorbid condition that could affect compliance with the protocol or interpretation of the results, which is to be judged at the discretion of the PI
• • History of hypersensitivity or other contraindication to contrast media
• • Contraindication to general anesthesia
• • Pregnancy