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Search / Trial NCT05904535

Novel Diagnostic Methods to Identify External Ventricular Drain Associated Infections

Launched by KAROLINSKA UNIVERSITY HOSPITAL · Jun 6, 2023

Trial Information

Current as of June 26, 2025

Recruiting

Keywords

ClinConnect Summary

This clinical trial is studying new ways to quickly identify infections that can occur when patients have an external ventricular drain, which is a tube used to help manage pressure in the brain. Currently, doctors often rely on indirect signs to decide if a patient has an infection and may start antibiotic treatment even when it isn't necessary. This trial will look at three new methods that could directly detect bacteria in the fluid around the brain, which may help doctors make better decisions about when to use antibiotics for patients in critical care.

To participate in this study, patients must be between the ages of 65 and 74 and be treated with an external ventricular drain while admitted to the neurocritical care unit at Karolinska University Hospital in Sweden. If eligible, participants can expect to undergo tests using these new diagnostic methods, and their results will be compared to the standard culture tests currently used. This research aims to improve how infections are diagnosed and treated, potentially leading to better care for patients with serious conditions.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • 1. Treated with an external ventricular drain.
  • 2. Admitted to the neurocritical and critical care unit at Karolinska University Hospital in Solna, Sweden.
  • Exclusion Criteria:
  • 1. Does not fulfill age requirements.

About Karolinska University Hospital

Karolinska University Hospital is a leading academic medical center in Sweden, renowned for its commitment to advanced healthcare research and innovative clinical practices. As a key sponsor of clinical trials, the hospital leverages its extensive expertise in medical research and collaboration with Karolinska Institutet, one of the world's foremost medical universities. The institution is dedicated to enhancing patient care through rigorous scientific investigation, focusing on a wide range of therapeutic areas. With a multidisciplinary approach and a strong emphasis on translational medicine, Karolinska University Hospital aims to bridge the gap between laboratory findings and clinical application, ultimately striving to improve health outcomes and advance medical knowledge.

Locations

Stockholm, , Sweden

Patients applied

0 patients applied

Trial Officials

David W Nelson, MD, PhD

Principal Investigator

Karolinska University Hospial, Karolinska Institutet

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported