AMP SCZ® Observational Study: PREDICT-DPACC

Launched by BRIGHAM AND WOMEN'S HOSPITAL · Jun 6, 2023

Keywords

ClinConnect Summary

The AMP SCZ Observational Study, known as PREDICT-DPACC, is focused on understanding young people who are at a higher risk of developing serious mental health issues, particularly psychosis. The goal of this study is to create tools that can help predict whether these individuals will improve, experience a psychotic episode, or have ongoing symptoms that affect their daily lives. By gathering information from a large group of participants aged 12 to 30, the researchers aim to identify patterns that may help in providing better treatments for those at risk.

To participate, individuals must be between 12 and 30 years old and meet specific criteria indicating they are at clinical high risk for psychosis. Participants will undergo various assessments over 18 to 24 months, allowing researchers to track their symptoms and overall well-being. Importantly, those with a history of certain mental health conditions or who are currently taking specific medications may not be eligible. This study is currently recruiting participants from multiple countries, making it a significant international effort to improve understanding and treatment of high-risk mental health conditions.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Individuals between 12 and 30 years old;
• • Understand and sign an informed consent (or assent for minors) document;
• • Meet diagnostic criteria for CHR from the Positive SYmptoms and Diagnostic Criteria for the CAARMS Harmonized with the SIPS (PSYCHS).
• Exclusion Criteria:
• • Antipsychotic medication exposure equivalent to a total lifetime haloperidol dose of \>50 mg or current antipsychotic medication at time of screening assessment;
• • Documented history of intellectual disability;
• • Past or current clinically relevant central nervous system disorder;
• • Traumatic brain injury that is rated as 7 or above on the Traumatic Brain Injury screening instrument;
• • Current or past treated or untreated psychotic episode, as determined using the PSYCHS.
• • See also the AMP SCZ website link for a description of eligibility criteria (https://www.ampscz.org/participate/eligible/).