Hypertonic Saline Solution to Prevent Acute Kidney Injury After Heart Transplantation

Launched by FERNANDO BACAL · Jun 9, 2023

Keywords

ClinConnect Summary

This clinical trial is studying whether a special type of salt water solution, called hypertonic saline, can help prevent kidney problems after a heart transplant. Acute kidney injury can happen shortly after surgery, and this study aims to see if using this solution can reduce the risk of these issues in patients who have just received a new heart.

To be eligible for this trial, patients need to be hospitalized and ready for an orthotopic heart transplant, which means they are getting a new heart placed in the same position as their old one. However, there are some conditions that would exclude someone from participating, such as needing kidney dialysis or having serious complications during surgery. If you or a loved one is considering this study, you can expect to receive careful monitoring and support during the early recovery period after the heart transplant while researchers gather important information about the effects of hypertonic saline.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Hospitalized patients submitted to orthotopic heart transplantation (HT)
• Exclusion Criteria:
• • Requirement of renal replacement therapy at the time of HT
• • Requirement of extracorporeal membrane oxygenation (ECMO) before or immediately after HT
• • Severe peri-operative mechanical complications
• • Double transplant (e.g. heart-kidney or heart-lung)
• • Hypernatremia (Na ≥ 145)
• • Severe hyponatremia (Na ≤ 120)