IVUS Guided PCI for CKD to Reduce CI-AKI

Launched by JILIN UNIVERSITY · Jun 13, 2023

Keywords

ClinConnect Summary

This clinical trial is looking at a new way to perform a heart procedure called percutaneous coronary intervention (PCI) for patients with coronary artery disease who also have chronic kidney disease. These patients are at higher risk of developing kidney problems after the procedure due to the use of a special dye called contrast. The trial will test whether using a technique called intravascular ultrasound (IVUS) can help use less contrast during the procedure, potentially reducing the risk of kidney injury.

To be eligible for this study, participants must be at least 18 years old and have coronary artery disease that requires a PCI, which may involve placing a stent in the heart. They should have a specific level of kidney function, as measured by a test called creatinine clearance. Participants will be randomly assigned to either the new IVUS-guided approach or standard care, and they can expect to be closely monitored throughout the process. Importantly, those with certain kidney issues, allergies to contrast dye, or other serious health concerns may not qualify for this trial. This research aims to improve the safety of heart procedures for patients with kidney problems, making it a significant step forward in care.

Gender

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Eligibility criteria

• Inclusion Criteria:
• • - age over 18 years coronary artery disease referred for percutaneous intervention, with stent, Drug coated bloon, or bioresorbable stent, of one or more epicardial vessel.
• • target lesion must be assessable by IVUS at baseline and during the procedure. 60ml/min/1.73m2\<=Baseline Calculated creatinine clearance \>=15ml/min/1.73m2 consent can be obtained and comply with all study procedures.
• Exclusion Criteria:
• • - Use of \>50ml of iodinated agent\<72 hours Planned used of iodinated contrast within 72 hours after the index procedure use of other nephrotoxic agents\<7 days known allergy to contrast agents unstable or unknown renal function prior to PCI life expectancy less than 1 year