Combined Respiratory Training in Persons with ALS

Launched by NOVA SOUTHEASTERN UNIVERSITY · Jun 13, 2023

Keywords

ClinConnect Summary

This clinical trial, called "Combined Respiratory Training in Persons with ALS," is exploring how two specific types of training—lung volume recruitment (LVR) and expiratory muscle strength training (EMST)—can help improve cough strength and breathing in people with ALS (Amyotrophic Lateral Sclerosis). The study aims to understand how these training methods can not only enhance lung function but also reduce feelings of breathlessness and improve overall quality of life for both patients and their caregivers.

To participate in this trial, individuals should be diagnosed with ALS within the last two years and should not have previously undergone these types of respiratory training. Participants will be closely monitored to see how their cough strength and respiratory function change during the training, and they will also share their experiences regarding any difficulties they face with swallowing or breathing. This study is currently recruiting participants aged between 18 and 75, regardless of gender, and it is important to note that those with certain other medical conditions may not be eligible. Overall, the trial provides an opportunity for ALS patients to contribute to research that could lead to better management of respiratory issues related to their condition.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. A diagnosis of probable or definite ALS in accordance with the Revisited El-Escorial Criteria.
• • 2. Disease duration from symptom onset of ≤ 2 years,
• • 3. Lung volume recruitment and expiratory muscle strength training naïve,
• • 4. Reduced peak cough flow (% predicted for age and gender).
• Exclusion Criteria:
• • 1. History of stroke, head and neck cancer or other concomitant disorder that might contribute to dysphagia or respiratory impairment.
• • 2. Use of prescription cough assist or non-invasive volume ventilation devices.
• • 3. Enrollment in another research investigation that might impact cough or respiratory function.
• • 4. Diagnosis of frontotemporal dementia or advanced cognitive impairment.
• • 5. Tracheostomy placement/Use of invasive mechanical ventilation.
• • 6. Contraindications for respiratory training (i.e., history of pneumothorax, severe chronic obstructive pulmonary disease).