NC Testing in LC & POTS

Launched by UNIVERSITY OF CALGARY · Jun 13, 2023

Keywords

ClinConnect Summary

This clinical trial is looking at how a treatment might help improve thinking and memory problems, often referred to as "brain fog," in people with Postural Orthostatic Tachycardia Syndrome (POTS) and those experiencing ongoing symptoms after COVID-19, known as Long COVID. Researchers will compare the effects of a larger dose of intravenous saline (a type of saltwater solution) with a smaller dose to see if the higher amount helps improve cognitive function better.

To participate, individuals must be diagnosed with Long COVID and have experienced symptoms for more than 12 weeks after testing positive for COVID-19. They should also have been diagnosed with POTS and report issues with cognitive function. The study welcomes healthy volunteers aged 18 to 60 who do not have POTS or "brain fog." Participants will receive an infusion and will be monitored for changes in their cognitive abilities during the study. It's a chance to contribute to important research that could help others facing similar challenges.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients with diagnosis of Long COVID
• • SARS-COV2 test positive
• • Symptoms \> 12 weeks post COVID
• • Subjective complaint of 'brain fog" or cognitive dysfunction
• • Patients with diagnosis of Postural Orthostatic Syndrome (POTS) from the Calgary Autonomic Investigation and Management Clinic
• • Subjective complaint of 'brain fog" or cognitive impairment
• • Healthy participants
• • Without POTS or "brain fog"
• • Age 18 to 60 years
• • Female and Male
• • Able to give an informed consent
• Exclusion Criteria:
• • Patients with overt causes for POTS (e.g., dehydration, prolonged bed rest)
• • An inability to safely withdraw from medicine(s) that could make test interpretation difficult and impossible.
• • Other factors which are in the investigator's opinion would prevent the participant from completing the protocol, including poor compliance during previous studies or an unpredictable schedule.
• • Unable to give an informed consent.