Production of Gut Microbiota-Derived Metabolites in Response to Different Fatty Acid Profiles

Launched by LAVAL UNIVERSITY · Jun 15, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how different types of fatty acids in our diet affect the production of substances from gut bacteria. Researchers want to see how meals rich in saturated fatty acids (often found in foods like butter and red meat) compare to meals rich in polyunsaturated fatty acids (found in foods like fish and nuts) in people with and without obesity and Type 2 diabetes. By understanding these processes, they hope to learn more about how our diets impact our health.

To participate, you need to be a man or woman between the ages of 45 and 65, with a body mass index (BMI) between 20 and 35, and in general good health. You should also have a decent diet quality score and be able to read basic French. Participants will need to avoid certain substances, like tobacco and some dietary supplements, and have not had major weight changes or specific health issues in the recent past. If you qualify and choose to join, you will help contribute to important research that may improve dietary recommendations for people with obesity and Type 2 diabetes.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Men and women aged between 45 and 65 years, menopaused women ;
• • Body mass index between 20 to 35 kg/m² ;
• • General good health ;
• • Score of diet quality (HEI) between 40 and 70 ;
• • Computer and Internet access ;
• • Basic understanding of written French ;
• • Daily stool frequency.
• Exclusion Criteria:
• • Intestinal pathologies including inflammatory bowel disease and gastrointestinal cancers ;
• • Alcohol consumption greater than 15 portions for men and 10 for women weekly.
• • Active tobacco and cannabis usage ;
• • Consumption of omega-3 dietary supplements ;
• • Consumption of dietary supplements (vitamins and probiotics) - must be ceased 2 weeks before the dietary intervention ;
• • Completion of a course of antibiotics in the past 3 months ;
• • Important weight change (+/- 5 kg) in the past 6 months ;
• • Type 1 diabetes or insulin-treated diabetes.