Modulation of Brain Oscillations Underlying Working Memory

Launched by MASSACHUSETTS GENERAL HOSPITAL · Jun 27, 2023

Keywords

ClinConnect Summary

This clinical trial is looking at how a new technique called transcranial alternating current stimulation (tACS) can help improve working memory, which is our ability to hold and use information in our minds for short periods. The study will involve applying gentle electrical currents to the scalp while measuring brain activity with a method called electroencephalography (EEG). This approach is noninvasive, meaning it doesn't require surgery or significant discomfort. Researchers hope to understand better how brain rhythms affect our memory.

To participate, you need to be between the ages of 65 and 74 and able to understand and provide consent in English. You won't be eligible if you have a history of neurological or psychiatric disorders, are currently taking certain medications, or have specific medical devices like pacemakers. If you join the study, you can expect a safe and supportive environment where your brain activity will be monitored as you engage in memory tasks. This trial is currently recruiting participants, and it's an exciting opportunity to contribute to research that could lead to new ways of enhancing memory function.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Able to provide informed consent
• • Fluent in English.
• Exclusion Criteria:
• • History of a neurological/psychiatric disorder
• • Current use of psychotropic medications
• • Current use of substances and drugs that were shown to affect tES (transcranial electrical stimulation) efficacy (dopamine altering drugs, nicotine, NMDA (N-methyl-D-aspartate) antagonists/agonists, sodium/calcium channel blockers, norepinephrine reuptake inhibitors, GABAergic modulators and selective serotonin reuptake inhibitors)
• • Contraindications for tACS (e.g., history of seizures, metallic implants in the head or neck, implanted brain stimulators, vagus nerve stimulators, pacemakers, pregnancy)