CAlgary SAlt for POTS

Launched by UNIVERSITY OF CALGARY · Jun 20, 2023

Keywords

ClinConnect Summary

The CAlgary SAlt for POTS clinical trial is investigating how a high salt diet impacts individuals with Postural Orthostatic Tachycardia Syndrome (POTS). POTS is a condition where patients experience a fast heartbeat when they stand up, which can lead to dizziness and other uncomfortable symptoms. This study aims to compare a high salt diet to a normal salt diet over three months to see how it affects symptoms and overall health. Participants will undergo various tests to measure their heart and blood function, as well as other related factors.

To be eligible for the trial, you should be between 18 and 60 years old and have a doctor’s diagnosis of POTS. You must not have other conditions that could cause similar symptoms, like dehydration or thyroid issues. If you live in Canada and can attend the Calgary Autonomic Research Clinic, this study could be a good fit for you. Throughout the trial, you can expect to participate in lab evaluations and receive guidance on your diet. This research is important because it will provide valuable information about the long-term effects of salt intake in managing POTS.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• * Physician Diagnosis of POTS as defined by the CCS Consensus Statement and as follows:
• • Sustained, excessive orthostatic tachycardia ≥ 30 bpm within 10 minutes standing.
• • Absence of orthostatic hypotension (\>20/10 mmHg decrease) within 3 minutes standing.
• • Chronic orthostatic symptoms that improve with recumbence.
• • Age 18-60 years old.
• • Ability to attend the Calgary Autonomic Research Clinic in Calgary.
• • Resident of Canada
• Exclusion Criteria:
• • Overt cause for postural tachycardia (i.e., acute dehydration, thyroid disease)
• • Participants with somatization or severe anxiety symptoms will be excluded
• • Pregnant (self-reported)
• • Underlying causes of tachycardia including acute hypovolemia, endocrinopathy, anemia, anxiety, medication effects, recreational drug effects, and prolonged bedrest.
• • Other factors which in the investigator's opinion would prevent the participant from completing the protocol, including poor compliance during previous studies
• • Fludrocortisone use (due to effects on renal Na+ handling)
• • Patients who have received IV saline in the 2 months preceding the study or who plan to receive it during the course of the study